| Title: |
Evaluating the association between blood genotype or phenotype and haemoplasma infection in UK and Italian cats |
| Authors: |
Spada, Eva; Galluzzo, Paola; Torina, Alessandra; Loria, Guido R.; Perego, Roberta; Grippi, Francesca; Blanda, Valeria; Baggiani, Luciana; D'Amico, Alessia; Pennisi, Maria G.; Helps, Chris R.; Malik, Richard; Westman, Mark; Gandolfi, Barbara; Spencer, Sarah; Proverbio, Daniela; Tasker, Séverine |
| Contributors: |
E. Spada; P. Galluzzo; A. Torina; G.R. Loria; R. Perego; F. Grippi; V. Blanda; L. Baggiani; A. D'Amico; M.G. Pennisi; C.R. Help; R. Malik; M. Westman; B. Gandolfi; S. Spencer; D. Proverbio; S. Tasker |
| Publisher Information: |
Wiley Blackwell Publishing |
| Publication Year: |
2022 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
AB group system; blood type; feline; haemotropic mycoplasma; infection; Settore VET/08 - Clinica Medica Veterinaria; Settore VET/05 - Malattie Infettive degli Animali Domestici |
| Description: |
Background: In humans, blood groups are associated with varying preva- lence of infections. The aim of this study was to determine if associations exist between the feline AB blood group system and haemoplasma infection. Methods: Data from two studies were combined. In the first study, DNA sam- ples from 131 haemoplasma-infected and 132 haemoplasma-uninfected UK cats underwent pyrosequencing to determine their blood genotype as AA, Ab or bb. In the second study, blood samples from 160 Italian cats of known blood phenotype A, B or AB underwent PCR testing for feline haemoplasma species DNA. Results: Haemoplasma infection was demonstrated in cats of all phenotypes and genotypes. A significantly higher number of Ab genotype cats tested pos- itive for overall haemoplasma infection status (p = 0.04) and for Mycoplasma haemofelis infection (p = 0.03). Limitations: Haemoplasma-infected Italian cats were few, possibly increas- ing the chance of type II error, and the presence of purebred cats in the sample population may have had a confounding effect. Conclusions: Feline haemoplasmas do not appear to preferentially use either blood type A or B antigens as attachment sites for erythrocyte colonisation. Further investigations in a larger number of haemoplasma-infected cats of known blood phenotype are warranted to explain the association between genotype Ab and haemoplasma infection. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36222468; info:eu-repo/semantics/altIdentifier/wos/WOS:000866123200001; firstpage:1; lastpage:9; numberofpages:9; journal:THE VETERINARY RECORD; https://hdl.handle.net/2434/940552 |
| DOI: |
10.1002/vetr.2282 |
| Availability: |
https://hdl.handle.net/2434/940552; https://doi.org/10.1002/vetr.2282 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.528F05F6 |
| Database: |
BASE |