| Title: |
NATEGLINIDE (STARLIX®): UPDATE ON A NEW ANTIDIABETIC AGENT |
| Authors: |
Phillips, LS; Dunning, BE |
| Source: |
International Journal of Clinical Practice ; volume 57, issue 6, page 535-541 ; ISSN 1368-5031 1742-1241 |
| Publisher Information: |
Wiley |
| Publication Year: |
2003 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
SUMMARY Nateglinide is a new oral antidiabetic agent that stimulates insulin release promptly after its pre‐meal administration in a strongly glucose‐dependent fashion. Because its insulinotropic effects are short in duration, nateglinide specifically targets postprandial hyperglycaemia with a low potential to elicit hypoglycaemia or sustained hyperinsulinaemia. Nateglinide has an excellent safety and tolerability profile, and its efficacy in reducing HbA 1c in monotherapy (120 mg before meals) is comparable to that of metformin, sulphonylureas, thiazolidinediones or acarbose (−0.5 to −1.5%). When combined with metformin, which primarily reduces fasting glucose levels, nateglinide's effects are additive. In our clinical experience, nateglinide is a particularly good therapeutic option in newly diagnosed, treatment‐naive patients; elderly patients in whom hypoglycaemia is a concern; patients with kidney failure or mild hepatic impairment; patients taking low‐dose sulphonylureas who encounter problems with hypoglycaemia; and patients failing to achieve adequate glycaemic control on metformin or thiazolidinedione monotherapy. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/j.1742-1241.2003.tb10546.x |
| Availability: |
http://dx.doi.org/10.1111/j.1742-1241.2003.tb10546.x; https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1742-1241.2003.tb10546.x |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.5297E848 |
| Database: |
BASE |