The burden of bacterial antimicrobial resistance in the WHO African region in 2019: a cross-country systematic analysis
| Title: | The burden of bacterial antimicrobial resistance in the WHO African region in 2019: a cross-country systematic analysis |
|---|---|
| Authors: | Sartorius, B; Gray, AP; Davis Weaver, N; Robles Aguilar, G; Swetschinski, LR; Ikuta, KS; Mestrovic, T; Chung, E; Wool, EE; Han, C; Gershberg Hayoon, A; Araki, DT; Abd-Elsalam, S; Aboagye, RG; Adamu, LH; Adepoju, AV; Ahmed, A; Akalu, GT; Akande-Sholabi, W; Amuasi, JH; Amusa, GA; Argaw, AM; Aruleba, RT; Awoke, T; Ayalew, MK; Azzam, AY; Babin, F-X; Banerjee, I; Basiru, A; Bayileyegn, NS; Belete, MA; Berkley, JA; Bielicki, JA; Dekker, D; Demeke, D; Demsie, DG; Dessie, AM; Dunachie, SJ; Ed-Dra, A; Ekholuenetale, M; Ekundayo, TC; El Sayed, I; Elhadi, M; Elsohaby, I; Eyre, D; Fagbamigbe, AF; Feasey, NA; Fekadu, G; Fell, F; Forrest, KM; Gebrehiwot, M; Gezae, KE; Ghazy, RM; Hailegiyorgis, TT; Haines-Woodhouse, G; Hasaballah, AI; Haselbeck, AH; Hsia, Y; Iradukunda, A; Iregbu, KC; Iwu, CCD; Iwu-Jaja, CJ; Iyasu, AN; Jaiteh, F; Jeon, H; Joshua, CE; Kassa, GG; Katoto, PDMC; Krumkamp, R; Kumaran, EAP; Kyu, HH; Manilal, A; Marks, F; May, J; McLaughlin, SA; McManigal, B; Melese, A; Misgina, KH; Mohamed, NS; Mohammed, M; Mohammed, S; Mokdad, AH; Moore, CE; Mougin, V; Mturi, N; Mulugeta, T; Musaigwa, F; Musicha, P; Musila, LA; Muthupandian, S; Naghavi, P; Negash, H; Nuckchady, DC; Obiero, CW; Odetokun, IA; Ogundijo, OA; Okidi, L; Okonji, OC; Olagunju, AT; Olufadewa, II; Pak, GD; Perovic, O; Pollard, A; Raad, M; Rafaï, C; Ramadan, H; Redwan, EMM; Roca, A; Rosenthal, VD; Saleh, MA; Samy, AM; Sharland, M; Shittu, A; Siddig, EE; Sisay, EA; Stergachis, A; Tesfamariam, WB; Tigoi, C; Tincho, MB; Tiruye, TY; Umeokonkwo, CD; Walsh, T; Walson, JL; Yusuf, H; Zeru, NG; Hay, SI; Dolecek, C; Murray, CJL; Naghavi, M |
| Publisher Information: | Elsevier BV |
| Publication Year: | 2024 |
| Collection: | St George's University of London: Repository |
| Description: | Background A critical and persistent challenge to global health and modern health care is the threat of antimicrobial resistance (AMR). Previous studies have reported a disproportionate burden of AMR in low-income and middle-income countries, but there remains an urgent need for more in-depth analyses across Africa. This study presents one of the most comprehensive sets of regional and country-level estimates of bacterial AMR burden in the WHO African region to date. Methods We estimated deaths and disability-adjusted life-years (DALYs) attributable to and associated with AMR for 23 bacterial pathogens and 88 pathogen–drug combinations for countries in the WHO African region in 2019. Our methodological approach consisted of five broad components: the number of deaths in which infection had a role, the proportion of infectious deaths attributable to a given infectious syndrome, the proportion of infectious syndrome deaths attributable to a given pathogen, the percentage of a given pathogen resistant to an antimicrobial drug of interest, and the excess risk of mortality (or duration of an infection) associated with this resistance. These components were then used to estimate the disease burden by using two counterfactual scenarios: deaths attributable to AMR (considering an alternative scenario where infections with resistant pathogens are replaced with susceptible ones) and deaths associated with AMR (considering an alternative scenario where drug-resistant infections would not occur at all). We obtained data from research hospitals, surveillance networks, and infection databases maintained by private laboratories and medical technology companies. We generated 95% uncertainty intervals (UIs) for final estimates as the 25th and 975th ordered values across 1000 posterior draws, and models were cross-validated for out-of-sample predictive validity. Findings In the WHO African region in 2019, there were an estimated 1·05 million deaths (95% UI 829 000–1 316 000) associated with bacterial AMR and 250 000 deaths (192 ... |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 2214-109X |
| Relation: | https://openaccess.sgul.ac.uk/id/eprint/116043/6/1-s2.0-S2214109X23005399-main.pdf; https://openaccess.sgul.ac.uk/id/eprint/116043/12/1-s2.0-S2214109X23005399-mmc1.pdf; Sartorius, B; Gray, AP; Davis Weaver, N; Robles Aguilar, G; Swetschinski, LR; Ikuta, KS; Mestrovic, T; Chung, E; Wool, EE; Han, C; et al. Sartorius, B; Gray, AP; Davis Weaver, N; Robles Aguilar, G; Swetschinski, LR; Ikuta, KS; Mestrovic, T; Chung, E; Wool, EE; Han, C; Gershberg Hayoon, A; Araki, DT; Abd-Elsalam, S; Aboagye, RG; Adamu, LH; Adepoju, AV; Ahmed, A; Akalu, GT; Akande-Sholabi, W; Amuasi, JH; Amusa, GA; Argaw, AM; Aruleba, RT; Awoke, T; Ayalew, MK; Azzam, AY; Babin, F-X; Banerjee, I; Basiru, A; Bayileyegn, NS; Belete, MA; Berkley, JA; Bielicki, JA; Dekker, D; Demeke, D; Demsie, DG; Dessie, AM; Dunachie, SJ; Ed-Dra, A; Ekholuenetale, M; Ekundayo, TC; El Sayed, I; Elhadi, M; Elsohaby, I; Eyre, D; Fagbamigbe, AF; Feasey, NA; Fekadu, G; Fell, F; Forrest, KM; Gebrehiwot, M; Gezae, KE; Ghazy, RM; Hailegiyorgis, TT; Haines-Woodhouse, G; Hasaballah, AI; Haselbeck, AH; Hsia, Y; Iradukunda, A; Iregbu, KC; Iwu, CCD; Iwu-Jaja, CJ; Iyasu, AN; Jaiteh, F; Jeon, H; Joshua, CE; Kassa, GG; Katoto, PDMC; Krumkamp, R; Kumaran, EAP; Kyu, HH; Manilal, A; Marks, F; May, J; McLaughlin, SA; McManigal, B; Melese, A; Misgina, KH; Mohamed, NS; Mohammed, M; Mohammed, S; Mohammed, S; Mokdad, AH; Moore, CE; Mougin, V; Mturi, N; Mulugeta, T; Musaigwa, F; Musicha, P; Musila, LA; Muthupandian, S; Naghavi, P; Negash, H; Nuckchady, DC; Obiero, CW; Odetokun, IA; Ogundijo, OA; Okidi, L; Okonji, OC; Olagunju, AT; Olufadewa, II; Pak, GD; Perovic, O; Pollard, A; Raad, M; Rafaï, C; Ramadan, H; Redwan, EMM; Roca, A; Rosenthal, VD; Saleh, MA; Samy, AM; Sharland, M; Shittu, A; Siddig, EE; Sisay, EA; Stergachis, A; Tesfamariam, WB; Tigoi, C; Tincho, MB; Tiruye, TY; Umeokonkwo, CD; Walsh, T; Walson, JL; Yusuf, H; Zeru, NG; Hay, SI; Dolecek, C; Murray, CJL; Naghavi, M (2024) The burden of bacterial antimicrobial resistance in the WHO African region in 2019: a cross-country systematic analysis. The Lancet Global Health, 12 (2). e201-e216. ISSN 2214-109X https://doi.org/10.1016/s2214-109x(23)00539-9 SGUL Authors: Moore, Catrin Elisabeth |
| DOI: | 10.1016/s2214-109x(23)00539-9 |
| Availability: | https://openaccess.sgul.ac.uk/id/eprint/116043/; https://doi.org/10.1016/s2214-109x(23)00539-9 |
| Rights: | cc_by_4 |
| Accession Number: | edsbas.52AE201 |
| Database: | BASE |