| Title: |
Comparison of the amyloid plaque proteome in Down syndrome, early-onset Alzheimer's disease, and late-onset Alzheimer's disease |
| Authors: |
Martá-Ariza, M.; Leitner, D.F.; Kanshin, E.; Suazo, J.; Giusti Pedrosa, A.; Thierry, M.; Lee, E.B.; Devinsky, O.; Drummond, E.; Fortea, Juan; Lleó, Alberto; Ueberheide, B.; Wisniewski, Thomas M. |
| Publication Year: |
2025 |
| Collection: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| Subject Terms: |
Alzheimer's disease; Amyloid-β; Down syndrome; Neuropathology; Proteomics |
| Description: |
Down syndrome (DS) is strongly associated with Alzheimer's disease (AD) due to APP overexpression, exhibiting Amyloid-β (Aβ) and Tau pathology similar to early-onset (EOAD) and late-onset AD (LOAD). We evaluated the Aβ plaque proteome of DS, EOAD, and LOAD using unbiased localized proteomics on post-mortem paraffin-embedded tissues from four cohorts (n = 20/group): DS (59.8 ± 4.99 y/o), EOAD (63 ± 4.07 y/o), LOAD (82.1 ± 6.37 y/o), and controls (66.4 ± 13.04). We identified differentially abundant proteins when comparing Aβ plaques and neighboring non-plaque tissue (FDR < 5%, fold-change. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
14320533 |
| Relation: |
Instituto de Salud Carlos III PI20/01473; Instituto de Salud Carlos III PI23/01786; Acta Neuropathologica; Vol. 149 Núm. 1 (june 2025), p. 9; https://ddd.uab.cat/record/320386; urn:oai:ddd.uab.cat:320386; urn:scopus_id:85216197698; urn:articleid:14320533v149n1a9; urn:oai:pubmedcentral.nih.gov:11742868; urn:pmid:39825890; urn:pmcid:PMC11742868 |
| Availability: |
https://ddd.uab.cat/record/320386 |
| Rights: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.52D4C858 |
| Database: |
BASE |