| Title: |
PET‐measured amyloid beta accumulates at an accelerated rate in Down syndrome compared to neurotypical populations |
| Authors: |
McVea, Andrew; DiFilippo, Alexandra; McLachlan, Max; Betcher, Brecca; Zammit, Matthew; Betthauser, Tobey J.; Converse, Alexander; Murali, Dhanabalan; Stone, Charles; Hartley, Sigan; Johnson, Sterling; Tudorascu, Dana L.; Laymon, Charles M.; Cohen, Ann D.; Minhas, Davneet; Luo, Weiquan; Mathis, Chester; Lao, Patrick J.; Ances, Beau; Zaman, Shahid; Mapstone, Mark; Head, Elizabeth; Handen, Benjamin L.; Christian, Bradley T. |
| Contributors: |
Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Aging |
| Source: |
Alzheimer's & Dementia ; volume 21, issue 6 ; ISSN 1552-5260 1552-5279 |
| Publisher Information: |
Wiley |
| Publication Year: |
2025 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
INTRODUCTION Individuals with Down syndrome (DS) have a high prevalence of Alzheimer's disease (AD) and reveal an earlier age of amyloid beta (Aβ) onset compared to sporadic AD. Differences in amyloid accumulation rates between DS and sporadic AD populations have not been established. METHODS Participants with ≥ 3 [C‐11]PiB scans (spanning > 6 years) and transitioning to Aβ+ were included, resulting in 20 DS and 23 neurotypical (NT) participants. Amyloid accumulation was compared using global standardized uptake value ratio (SUVR) for Aβ deposition, with individual growth rates ( r ) estimated using the logistic growth model (). RESULTS The average growth rate in the DS cohort was 0.28 (0.08)/year versus 0.20 (0.08)/year for NT (), an increase of 40%. DISCUSSION Using individual longitudinal analyses, accelerated amyloid accumulation in DS is observed, This has important considerations for informing treatment trial design and monitoring beta‐amyloid changes in future AD studies involving individuals with DS. Highlights Aβ accumulation rate was estimated using a logistic growth model. There was no overlap in the age of amyloid positivity between DS and NT cohorts. Participants with DS accumulate amyloid 40% faster than those with sporadic AD. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/alz.70357 |
| Availability: |
https://doi.org/10.1002/alz.70357; https://alz-journals.onlinelibrary.wiley.com/doi/pdf/10.1002/alz.70357 |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.52EC6F2 |
| Database: |
BASE |