| Title: |
Nucleoli and Stress Granules: Connecting Distant Relatives |
| Authors: |
Mahboubi, Hicham; Stochaj, Ursula |
| Contributors: |
Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies; Heart and Stroke Foundation of Canada |
| Source: |
Traffic ; volume 15, issue 10, page 1179-1193 ; ISSN 1398-9219 1600-0854 |
| Publisher Information: |
Wiley |
| Publication Year: |
2014 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Nucleoli and cytoplasmic stress granules ( SGs ) are subcellular compartments that modulate the response to endogenous and environmental signals to control cell survival. In our opinion, nucleoli and SGs are functionally linked; they are distant relatives that combine forces when cellular homeostasis is threatened. Several lines of evidence support this idea; nucleoli and SGs share molecular building blocks, are regulated by common signaling pathways and communicate when vital cellular functions become compromised. Together, nucleoli and SGs orchestrate physiological responses that are directly relevant to stress and human health. As both compartments have established roles in neurodegenerative diseases, cancer and virus infections, we propose that these conditions will benefit from therapeutic interventions that target simultaneously nucleoli and SGs . |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/tra.12191 |
| Availability: |
https://doi.org/10.1111/tra.12191; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Ftra.12191; https://onlinelibrary.wiley.com/doi/pdf/10.1111/tra.12191 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.535BDA76 |
| Database: |
BASE |