| Title: |
IL-22 driven neutrophils afford critical protection from acute murine cytomegalovirus infection (P6310) |
| Authors: |
Stacey, Maria; Marsden, Morgan; Dolton, Garry; Stack, Gabrielle; Jones, Emma; Taylor, Philip; Jones, Simon; Snelgrove, Robert; Wilkinson, Gavin; Humphreys, Ian |
| Source: |
The Journal of Immunology ; volume 190, issue Supplement_1, page 182.7-182.7 ; ISSN 0022-1767 1550-6606 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2013 |
| Description: |
Pathogenic herpesviruses including cytomegalovirus target numerous host organs during infection, but the immunological mechanisms that afford antiviral protection in different tissue microenvironments require a better understanding. Utilizing the murine cytomegalovirus (MCMV) model, we demonstrate that neutrophils are critical antiviral effector cells that counter acute herpesvirus infection. Depletion of Ly6G+ neutrophils exacerbated virus-induced weight loss and elevated virus load in a tissue-restricted manner. Neutrophils profoundly and directly inhibited virus replication in vitro. MCMV-elicited neutrophil responses were orchestrated by interleukin-22 (IL-22), which was expressed by conventional NK cells and induced neutrophil-attractant chemokines in MCMV-infected peripheral organs. These data demonstrate that IL-22 affords anti-herpesvirus infection in peripheral tissue and highlights a previously unappreciated and critical role for neutrophils in countering cytomegalovirus infection. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.4049/jimmunol.190.supp.182.7 |
| Availability: |
https://doi.org/10.4049/jimmunol.190.supp.182.7; https://academic.oup.com/jimmunol/article/190/Supplement_1/182.7/7999350 |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.535DA8AC |
| Database: |
BASE |