Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury
| Title: | Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury |
|---|---|
| Authors: | Guo, Zhen; Valenzuela Ripoll, Carla; Picataggi, Antonino; Rawnsley, David R.; Ozcan, Mualla; Chirinos, Julio A.; Chendamarai, Ezhilarasi; Girardi, Amanda; Riehl, Terrence; Evie, Hosannah; Diab, Ahmed; Kovacs, Attila; Hyrc, Krzysztof; Ma, Xiucui; Asnani, Aarti; Shewale, Swapnil V.; Scherrer-Crosbie, Marielle; Cowart, Lauren Ashley; Parks, John S.; Zhao, Lei; Gordon, David; Ramirez-Valle, Francisco; Margulies, Kenneth B.; Cappola, Thomas P.; Desai, Ankit A.; Pedersen, Lauren N.; Bergom, Carmen; Stitziel, Nathan O.; Rettig, Michael P.; DiPersio, John F.; Hajny, Stefan; Christoffersen, Christina; Diwan, Abhinav; Javaheri, Ali |
| Source: | Guo , Z , Valenzuela Ripoll , C , Picataggi , A , Rawnsley , D R , Ozcan , M , Chirinos , J A , Chendamarai , E , Girardi , A , Riehl , T , Evie , H , Diab , A , Kovacs , A , Hyrc , K , Ma , X , Asnani , A , Shewale , S V , Scherrer-Crosbie , M , Cowart , L A , Parks , J S , Zhao , L , Gordon , D , Ramirez-Valle , F , Margulies , K B , .... |
| Publication Year: | 2023 |
| Collection: | University of Copenhagen: Research / Forskning ved Københavns Universitet |
| Subject Terms: | anthracycline; apolipoprotein M; autophagy; cardiomyopathy; TFEB |
| Description: | Apolipoprotein M (ApoM) binds sphingosine-1-phosphate (S1P) and is inversely associated with mortality in human heart failure (HF). Here, we show that anthracyclines such as doxorubicin (Dox) reduce circulating ApoM in mice and humans, that ApoM is inversely associated with mortality in patients with anthracycline-induced heart failure, and ApoM heterozygosity in mice increases Dox-induced mortality. In the setting of Dox stress, our studies suggest ApoM can help sustain myocardial autophagic flux in a post-transcriptional manner, attenuate Dox cardiotoxicity, and prevent lysosomal injury. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| DOI: | 10.1016/j.jacbts.2022.09.010 |
| Availability: | https://researchprofiles.ku.dk/da/publications/95d1089f-6a8f-406e-b690-fec872101a75; https://doi.org/10.1016/j.jacbts.2022.09.010; https://curis.ku.dk/ws/files/359175695/Apolipoprotein.pdf; http://www.scopus.com/inward/record.url?scp=85150029297&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.53909C7D |
| Database: | BASE |