| Title: |
The Impact of Supplemental Antioxidants on Visual Function in Nonadvanced Age-Related Macular Degeneration: A Head-to-Head Randomized Clinical Trial |
| Authors: |
Akuffo, Kwadwo Owusu; Beatty, Stephen; Peto, Tunde; Stack, Jim; Stringham, Jim; Kelly, David; Leung, Irene; Corcoran, Laura; Nolan, John M |
| Source: |
Akuffo, K O, Beatty, S, Peto, T, Stack, J, Stringham, J, Kelly, D, Leung, I, Corcoran, L & Nolan, J M 2017, 'The Impact of Supplemental Antioxidants on Visual Function in Nonadvanced Age-Related Macular Degeneration: A Head-to-Head Randomized Clinical Trial', Investigative ophthalmology & visual science, vol. 58, no. 12, pp. 5347-5360. https://doi.org/10.1167/iovs.16-21192 |
| Publication Year: |
2017 |
| Collection: |
Queen's University Belfast: Research Portal |
| Subject Terms: |
Aged; Antioxidants; Ascorbic Acid; Contrast Sensitivity; Double-Blind Method; Drug Therapy; Combination; Female; Glare; Humans; Lutein; Macular Degeneration; Macular Pigment; Male; Middle Aged; Photometry; Reading; Trace Elements; Visual Acuity; Vitamin E; Zeaxanthins; Zinc; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support; Non-U.S. Gov't |
| Description: |
Purpose: The purpose of this study was to evaluate the impact of supplemental macular carotenoids (including versus not including meso-zeaxanthin) in combination with coantioxidants on visual function in patients with nonadvanced age-related macular degeneration. Methods: In this study, 121 participants were randomly assigned to group 1 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc and an addition of 10 mg meso-zeaxanthin; n = 60) or group 2 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc; n = 61). Visual function was assessed using best-corrected visual acuity, contrast sensitivity (CS), glare disability, retinal straylight, photostress recovery time, reading performance, and the National Eye Institute Visual Function Questionnaire-25. Macular pigment was measured using customized heterochromatic flicker photometry. Results: There was a statistically significant improvement in the primary outcome measure (letter CS at 6 cycles per degree [6 cpd]) over time (P = 0.013), and this observed improvement was statistically comparable between interventions (P = 0.881). Statistically significant improvements in several secondary outcome visual function measures (letter CS at 1.2 and 2.4 cpd; mesopic and photopic CS at all spatial frequencies; mesopic glare disability at 1.5, 3, and 6 cpd; photopic glare disability at 1.5, 3, 6, and 12 cpd; photostress recovery time; retinal straylight; mean and maximum reading speed) were also observed over time (P < 0.05, for all), and were statistically comparable between interventions (P > 0.05, for all). Statistically significant increases in macular pigment at all eccentricities were observed over time (P < 0.0005, for all), and the degree of augmentation was statistically comparable between interventions (P > 0.05). Conclusions: Antioxidant supplementation in patients with nonadvanced age-related macular degeneration results in significant increases in macular pigment and improvements in CS and other measures ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0146-0404; 1552-5783 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/29053808; info:eu-repo/semantics/altIdentifier/pissn/0146-0404; info:eu-repo/semantics/altIdentifier/eissn/1552-5783 |
| DOI: |
10.1167/iovs.16-21192 |
| Availability: |
https://pure.qub.ac.uk/en/publications/bc4d5920-4a8f-485e-b051-75f8c8832438; https://doi.org/10.1167/iovs.16-21192; https://pureadmin.qub.ac.uk/ws/files/148786925/i1552_5783_58_12_5347.pdf; https://www.scopus.com/pages/publications/85032143463 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.53CEF24A |
| Database: |
BASE |