| Title: |
Predictors of Atrial Fibrillation in Patients With Stroke Attributed to Large- or Small-Vessel Disease ; A Prespecified Secondary Analysis of the STROKE AF Randomized Clinical Trial |
| Authors: |
Schwamm, Lee H.; Kamel, Hooman; Granger, Christopher B.; Piccini, Jonathan P.; Katz, Jeffrey M.; Sethi, Pramod P.; Sidorov, Evgeny V.; Kasner, Scott E.; Silverman, Scott B.; Merriam, Theodore T.; Franco, Noreli; Ziegler, Paul D.; Bernstein, Richard A.; Abi-Samra, Freddy; Acosta, Indrani; Al Balushi, Ali; Al-Awwad, Ahmad; Alimohammad, Rizwan; Alkahalifah, Moayd; Allred, James; Alsorogi, Mohammad; Arias, Valerie; Aroor, Sushanth; Arora, Rohan; Asdaghi, Negar; Asi, Khaled; Assar, Manish; Badhwar, Nitish; Banchs, Javier; Bansal, Sandeep; Barrett, Conor; Beaver, Bahar; Beldner, Stuart; Belt, Gary; Bernabei, Matthew; Bernard, Michael; Bhatt, Nirav; Black, James; Bledsoe, Don; Bonaguidi, Heather; Bonyak, Kay; Boyd, Clara; Cajavilca, Christian; Caprio, Frances; Carter, Jacqueline; Chancellor, Breehan; Chang, Cherylee; Chaudhary, Gauhar; Chaudhary, Shuchi; Cheung, Peter |
| Source: |
JAMA Neurology ; volume 80, issue 1, page 99 ; ISSN 2168-6149 |
| Publisher Information: |
American Medical Association (AMA) |
| Publication Year: |
2023 |
| Description: |
Importance The Stroke of Known Cause and Underlying Atrial Fibrillation (STROKE AF) trial found that approximately 1 in 8 patients with recent ischemic stroke attributed to large- or small-vessel disease had poststroke atrial fibrillation (AF) detected by an insertable cardiac monitor (ICM) at 12 months. Identifying predictors of AF could be useful when considering an ICM in routine poststroke clinical care. Objective To determine the association between commonly assessed risk factors and poststroke detection of new AF in the STROKE AF cohort monitored by ICM. Design, Setting, and Participants This was a prespecified analysis of a randomized (1:1) clinical trial that enrolled patients between April 1, 2016, and July 12, 2019, with primary follow-up through 2020 and mean (SD) duration of 11.0 (3.0) months. Eligible patients were selected from 33 clinical research sites in the US. Patients had an index stroke attributed to large- or small-vessel disease and were 60 years or older or aged 50 to 59 years with at least 1 additional stroke risk factor. A total of 496 patients were enrolled, and 492 were randomly assigned to study groups (3 did not meet inclusion criteria, and 1 withdrew consent). Patients in the ICM group had the index stroke within 10 days before insertion. Data were analyzed from October 8, 2021, to January 28, 2022. Interventions ICM monitoring vs site-specific usual care (short-duration external cardiac monitoring). Main Outcomes and Measures The ICM device automatically detects AF episodes 2 or more minutes in length; episodes were adjudicated by an expert committee. Cox regression multivariable modeling included all parameters identified in the univariate analysis having P values |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1001/jamaneurol.2022.4038 |
| Availability: |
https://doi.org/10.1001/jamaneurol.2022.4038; https://jamanetwork.com/journals/jamaneurology/articlepdf/2798590/jamaneurology_schwamm_2022_br_220008_1672852459.31563.pdf |
| Accession Number: |
edsbas.53EAFDD8 |
| Database: |
BASE |