| Title: |
Personality Related to Quality-of-Life Improvement After Deep Brain Stimulation in Parkinson's Disease (PSYCHO-STIM II). |
| Authors: |
Boussac, Mathilde; Arbus, Christophe; Klinger, Helene; Eusebio, Alexandre; Hainque, Elodie; Christophe Corvol, Jean; Rascol, Olivier; Rousseau, Vanessa; Harroch, Estelle; D'apollonia, Charlotte Scotto; Croiset, Aurélie; Ory-Magne, Fabienne; De Barros, Amaury; Fabbri, Margherita; Moreau, caroline; Rolland, Anne-Sophie; Benatru, Isabelle; Anheim, Mathieu; Marques, Ana-Raquel; Maltête, David; Drapier, Sophie; Jarraya, Béchir; Hubsch, Cécile; Guehl, Dominique; Meyer, Mylène; Rouaud, Tiphaine; Giordana, Bruno; Tir, Mélissa; Devos, David; Brefel-Courbon, Christine |
| Contributors: |
Université de Lille; Inserm; CHU Lille; Université de Toulouse UT; Aix Marseille Université AMU; Sorbonne Université - Faculté de Médecine SU FM; Sorbonne Université SU; Université Toulouse - Jean Jaurès UT2J; Lille Neurosciences & Cognition (LilNCog) - U 1172; Université de Poitiers = University of Poitiers UP; Université de Strasbourg UNISTRA; Université Clermont Auvergne UCA; Université de Rouen Normandie UNIROUEN; Université Paris-Saclay; Université de Bordeaux UB; Université de Picardie Jules Verne UPJV |
| Publication Year: |
2024 |
| Collection: |
LillOA (Lille Open Archive - Université de Lille) |
| Subject Terms: |
Cooperativeness; DBS-STN; novelty seeking; Parkinson's disease; quality of life |
| Description: |
Background: Deep brain stimulation of the sub-thalamic nucleus (DBS-STN) reduces symptoms in Parkinson’s disease (PD) patients with motor fluctuations. However, some patients may not feel ameliorated afterwards, despite an objective motor improvement. It is thus important to find new predictors of patients’ quality of life (QoL) amelioration after DBS-STN. We hypothesized that personality dimensions might affect QoL after DBS-STN. Objective: To evaluate associations between personality dimensions and QoL improvement one year after DBS-STN. Methods: DBS-STN-PD patients (n = 303) having answered the “Temperament and Character Inventory” (TCI) before surgery and the PDQ-39 before and one year after surgery were included, from the cohort study PREDI-STIM. Linear regression models were used to evaluate associations between TCI dimensions and change in PDQ-39 scores after DBS-STN. Results: Novelty Seeking and Cooperativeness scores before surgery were positively associated with PDQ-39 scores improvement after DBS-STN (FDR-adjusted p < 0.01). Moreover, paradoxically unimproved patients with deterioration of their PDQ-39 scores after DBS-STN despite improvement of their MDS-UPDRS-IV scores had lower Cooperativeness scores, while paradoxically improved patients with amelioration of their PDQ-39 scores despite deterioration of their MDS-UPDRS-IV scores had higher Reward Dependence scores. Conclusion: Some presurgical personality dimensions were significantly associated with QoL amelioration and discrepancy between motor state and QoL changes after DBS-STN in PD. Educational programs before DBS-STN should take in account patient personality dimensions to better deal with their expectations. ; 12 |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/octet-stream |
| Language: |
English |
| ISSN: |
34897100 |
| Relation: |
Journal of Parkinson's disease; J Parkinsons Dis; http://hdl.handle.net/20.500.12210/115447 |
| Availability: |
https://hdl.handle.net/20.500.12210/115447 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.53EB0B9E |
| Database: |
BASE |