| Title: |
Analytical and Bioanalytical Methods for the Quantification of the Nucleotide Polymerase Inhibitor - Sofosbuvir: A Critical Review (2015-2021) |
| Authors: |
Pathak, Shilpi; Bhardwaj, Muskan; Godela, Ramreddy |
| Source: |
Current Pharmaceutical Analysis ; volume 19, issue 1, page 51-65 ; ISSN 1573-4129 |
| Publisher Information: |
Elsevier BV |
| Publication Year: |
2023 |
| Collection: |
ScienceDirect (Elsevier - Open Access Articles via Crossref) |
| Description: |
Sofosbuvir is a regularly used antiviral medication that was approved for clinical usage in hepatitis C patients. Sofosbuvir belongs to the nucleotide analog drug class, and it operates by inhibiting hepatitis C NS5B protein. This study focuses on the many analytical methods for detecting and quantifying Sofosbuvir in pharmaceutical formulations, biological samples, and fixed dosage combinations. Chromatographic techniques, electro-analytical methods, chemometric procedures, and optical approaches are just a few of the approaches mentioned in the literature. The most often used methods for the analysis of Sofosbuvir are HPLC-based methods with UV/Vis spectrophotometric, fluorescence, and mass spectrometric detection. This article could be extremely useful in the creation of upcoming Sofosbuvir analytical approaches or investigations. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.2174/1573412918666221011112422 |
| Availability: |
https://doi.org/10.2174/1573412918666221011112422; https://www.eurekaselect.com/article/download?doi=10.2174/1573412918666221011112422; https://www.eurekaselect.com/209850/article |
| Accession Number: |
edsbas.540DDF7A |
| Database: |
BASE |