| Title: |
Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study |
| Authors: |
Swift, AJ; Wilson, F; Cogliano, M; Kendall, L; Alandejani, F; Alabed, S; Hughes, P; Shahin, Y; Saunders, L; Oram, C; Capener, D; Rothman, A; Garg, P; Johns, C; Austin, M; Macdonald, A; Pickworth, J; Hickey, P; Condliffe, R; Cahn, A; Lawrie, A; Wild, JM; Kiely, DG |
| Source: |
1035 ; 1032 |
| Publisher Information: |
BMJ Publishing Group |
| Publication Year: |
2021 |
| Collection: |
Imperial College London: Spiral |
| Description: |
End points that are repeatable and sensitive to change are important in pulmonary arterial hypertension (PAH) for clinical practice and trials of new therapies. In 42 patients with PAH, test–retest repeatability was assessed using the intraclass correlation coefficient and treatment effect size using Cohen’s d statistic. Intraclass correlation coefficients demonstrated excellent repeatability for MRI, 6 min walk test and log to base 10 N-terminal pro-brain natriuretic peptide (log10NT-proBNP). The treatment effect size for MRI-derived right ventricular ejection fraction was large (Cohen’s d 0.81), whereas the effect size for the 6 min walk test (Cohen’s d 0.22) and log10NT-proBNP (Cohen’s d 0.20) were fair. This study supports further evaluation of MRI as a non-invasive end point for clinical assessment and PAH therapy trials. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Thorax; http://hdl.handle.net/10044/1/109623 |
| DOI: |
10.1136/thoraxjnl-2020-216078 |
| Availability: |
http://hdl.handle.net/10044/1/109623; https://doi.org/10.1136/thoraxjnl-2020-216078 |
| Rights: |
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.544248CB |
| Database: |
BASE |