| Title: |
Landscape of transcription in human cells |
| Authors: |
Djebali, Sarah; Davis, Carrie A.; Merkel, Angelika; Dobin, Alex; Lassmann, Timo; Mortazavi, Ali; Tanzer, Andrea; Lagarde, Julien; Lin, Wei; Schlesinger, Felix; Xue, Chenghai; Marinov, Georgi K.; Khatun, Jainab; Williams, Brian A.; Zaleski, Chris; Rozowsky, Joel; Röder, Maik; Kokocinski, Felix; Abdelhamid, Rehab F.; Alioto, Tyler; Antoshechkin, Igor; Baer, Michael T.; Bar, Nadav S; Batut, Philippe; Bell, Kimberly; Bell, Ian; Chakrabortty, Sudipto; Chen, Xian; Chrast, Jacqueline; Curado, Joao; Derrien, Thomas; Drenkow, Jorg; Dumais, Erica; Dumais, Jacqueline; Duttagupta, Radha; Falconnet, Emilie; Fastuca, Meagan; Fejes-Toth, Kata; Ferreira, Pedro; Foissac, Sylvain; Fullwood, Melissa J; Gao, Hui; Gonzalez, David; Gordon, Assaf; Gunawardena, Harsha; Howald, Cedric; Jha, Sonali; Johnson, Rory; Kapranov, Philipp; King, Brandon; Kingswood, Colin; Luo, Oscar J; Park, Eddie; Persaud, Kimberly; Preall, Jonathan B.; Ribeca, Paolo; Risk, Brian; Robyr, Daniel; Sammeth, Michael; Schaffer, Lorian; See, Lei-Hoon; Shahab, Atif; Skancke, Jorgen; Suzuki, Ana Maria; Takahashi, Hazuki; Tilgner, Hagen; Trout, Diane; Walters, Nathalie; Wang, Huaien; Wrobel, John; Yu, Yanbao; Ruan, Xiaoan; Hayashizaki, Yoshihide; Harrow, Jennifer; Gerstein, Mark; Hubbard, Tim; Reymond, Alexandre; Antonarakis, Stylianos E; Hannon, Gregory; Giddings, Morgan C; Ruan, Yijun; Wold, Barbara; Carninci, Piero; Guigó, Roderic; Gingeras, Thomas R |
| Contributors: |
Centre for Genomic Regulation - Centre de Regulació Genòmica Barcelona (CRG); Universitat Pompeu Fabra Barcelona (UPF)-Centro Nacional de Analisis Genomico Barcelona (CNAG); Universitat Pompeu Fabra Barcelona (UPF); Cold Spring Harbor Laboratory; Riken Yokohama Institute; California Institute of Technology (CALTECH); University of California Irvine (UC Irvine); University of California (UC); Boise State University; Yale University New Haven; The Wellcome Trust Sanger Institute Cambridge; Centro Nacional de Analisis Genomico Barcelona (CNAG); Norwegian University of Science and Technology Trondheim (NTNU); Norwegian University of Science and Technology = Norges Teknisk-Naturvitenskapelige Universitet = Norjan teknis-luonnontieteellinen yliopisto (NTNU); Affymetrix Inc.; Université de Caroline du Nord à Chapel Hill = University of North Carolina Chapel Hill (UNC-Chapel Hill); University of North Carolina System (UNC); Université de Lausanne = University of Lausanne (UNIL); Laboratoire de Génétique Cellulaire (LGC); Institut National de la Recherche Agronomique (INRA)-École nationale vétérinaire de Toulouse (ENVT); Institut National Polytechnique (Toulouse) (Toulouse INP); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National Polytechnique (Toulouse) (Toulouse INP); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse); Université de Genève = University of Geneva (UNIGE); (IGE3 Inst Genet & Genom Geneva); University of Geneva Medical School; Genome Institute of Singapore (GIS); St Laurent Institut |
| Source: |
ISSN: 0028-0836. |
| Publisher Information: |
CCSD; Nature Publishing Group |
| Publication Year: |
2012 |
| Collection: |
Université Toulouse III - Paul Sabatier: HAL-UPS |
| Subject Terms: |
map; expression; identification; enhancer; genome; small rnas; [SDV]Life Sciences [q-bio] |
| Description: |
Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell's regulatory capabilities are focused on its synthesis, processing, transport, modification and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three-quarters of the human genome is capable of being transcribed, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs. These observations, taken together, prompt a redefinition of the concept of a gene. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISBN: |
978-0-00-308347-7; 0-00-308347-0 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/22955620; PRODINRA: 322248; PUBMED: 22955620; WOS: 000308347000043 |
| DOI: |
10.1038/nature11233 |
| Availability: |
https://hal.science/hal-01216755; https://hal.science/hal-01216755v1/document; https://hal.science/hal-01216755v1/file/Nature%20%20%202012%20%20%20489%20%20%207414%20%20%20%20Djebali%20%20%20101-108_%7B1341E669-1001-41D0-BB13-EAE31E3BB5F1%7D.pdf; https://doi.org/10.1038/nature11233 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.54445F4B |
| Database: |
BASE |