| Title: |
Brain Glucose Metabolism in Cerebral Amyloid Angiopathy |
| Authors: |
Bergeret, Sébastien; Queneau, Mathieu; Rodallec, Mathieu; Landeau, Brigitte; Chetelat, Gaël; Hong, Young, T; Dumurgier, Julien; Hugon, Jacques; Paquet, Claire; Farid, Karim; Baron, Jean-Claude |
| Contributors: |
Université des Antilles (UA); Centre cardiologique du Nord (CCN); Physiopathologie et imagerie des troubles neurologiques (PhIND); Université de Caen Normandie (UNICAEN); Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM); GIP Cyceron (Cyceron); Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie (CHU Caen Normandie); Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); University of Cambridge Cambridge, UK (CAM); Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S 1144 / U1144)); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Centre Hospitalier Sainte Anne Paris; Université Paris Cité (UPCité); Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm) |
| Source: |
ISSN: 0039-2499. |
| Publisher Information: |
CCSD; American Heart Association |
| Publication Year: |
2021 |
| Subject Terms: |
Alzheimer disease; cerebral small vessel diseases; cognitive impairment; microbleeds; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Description: |
International audience ; Background and Purpose: The in vivo diagnosis of cerebral amyloid angiopathy (CAA) is currently based on the Boston criteria, which largely rely on hemorrhagic features on brain magnetic resonance imaging. Adding to these criteria 18 F-fluoro-deoxy-D-glucose (FDG) positron emission tomography, a widely available imaging modality, might improve their accuracy. Here we tested the hypothesis that FDG uptake is reduced in posterior cortical areas, particularly the primary occipital cortex, which pathologically bear the brunt of vascular Aβ deposition. Methods: From a large memory clinic database, we retrospectively included all patients in whom both brain magnetic resonance imaging and FDG positron emission tomography had been obtained as part of routine clinical care and who fulfilled the Boston criteria for probable CAA. None had a history of symptomatic intracerebral hemorrhage. FDG data processing involved (1) spatial normalization to the Montreal Neurology Institute/International Consortium for Brain Mapping 152 space and (2) generation of standardized FDG uptake (relative standardized uptake value; relative to the pons). The relative standardized uptake value data obtained in 13 regions of interest sampling key cortical areas and the cerebellum were compared between the CAA and age-matched control groups using 2 separate healthy subject databases and image-processing pipelines. The presence of significant hypometabolism (2-tailed P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/33611942; PUBMED: 33611942 |
| DOI: |
10.1161/strokeaha.120.032905 |
| Availability: |
https://inserm.hal.science/inserm-03280309; https://inserm.hal.science/inserm-03280309v1/document; https://inserm.hal.science/inserm-03280309v1/file/Bergeret%20et%20al.%20Stroke.%202021.pdf; https://doi.org/10.1161/strokeaha.120.032905 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ |
| Accession Number: |
edsbas.5464F02D |
| Database: |
BASE |