| Title: |
Immune Response to MVA-BN and Prior Smallpox Vaccination in People With HIV or at Risk for HIV Acquisition |
| Authors: |
Li, Yijia; Townsend, Michael B; Li, Shanshan; Testa, Quinn E; Medvec, Tom; Thompson, Elizabeth A; Palella, Frank J; Mimiaga, Matthew J; Brock, James B; Alcaide, Maria L; Sheth, Anandi N; Floris-Moore, Michelle; Chandran, Aruna; French, Audrey L; Tien, Phyllis C; Merenstein, Daniel J; Augenbraun, Michael; Sharma, Anjali; Moran, Caitlin A; Rinaldo, Charles R; Macatangay, Bernard J C; Satheshkumar, Panayampalli S; Ho, Ken S |
| Contributors: |
MACS; WIHS; MWCCS; National Institutes of Health; Centers for Disease Control and Prevention; Atlanta CRS; Baltimore CRS; Bronx CRS; Brooklyn CRS; Data Analysis and Coordination Center; Chicago-Cook County CRS; Chicago-Northwestern CRS; National Heart, Lung, and Blood Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Aging; National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Drug Abuse; NIDA; Nursing; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; National Institute on Deafness and Other Communication Disorders; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Minority Health and Health Disparities; Office of AIDS Research; UCSF; CTSA; JHU; ICTR; UCLA CTSI; CFAR; UNC CFAR; UAB CFAR |
| Source: |
Open Forum Infectious Diseases ; volume 12, issue 8 ; ISSN 2328-8957 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Description: |
Little is known about the serologic response elicited by the Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccination (JYNNEOS) against mpox in elderly individuals with or without HIV. In this study, we measured levels of antibody against orthopoxvirus in selected participants (n = 114) with HIV or at risk for HIV acquisition from the Multicenter AIDS Cohort Study/Women's Interagency HIV Study Combined Cohort Study, who had no prior reported history of mpox. Participants reported MVA-BN vaccination history via questionnaires. The median age was 64 years, 24.6% were female, and 46% were HIV seropositive. Twenty out of 114 participants received at least 1 dose of MVA-BN. We found that MVA-BN induced sustained IgG levels regardless of HIV status, even up to 1 year. Birth before 1973 was correlated with higher IgG. MVA-BN-unvaccinated individuals with HIV had lower IgG than those without HIV. Although limited by small sample size, our study is among the first to assess anti-orthopoxvirus antibodies specifically in a vulnerable, older population and stratified by HIV status. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ofid/ofaf497 |
| DOI: |
10.1093/ofid/ofaf497/64046240/ofaf497.pdf |
| Availability: |
https://doi.org/10.1093/ofid/ofaf497; https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofaf497/64046240/ofaf497.pdf; https://academic.oup.com/ofid/article-pdf/12/8/ofaf497/64046240/ofaf497.pdf |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.546C7ED2 |
| Database: |
BASE |