Prognostic Factors of Late-onset Hearing Loss in Infants With Congenital Cytomegalovirus and Normal Audiologic Assessment at Birth
| Title: | Prognostic Factors of Late-onset Hearing Loss in Infants With Congenital Cytomegalovirus and Normal Audiologic Assessment at Birth |
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| Authors: | Buonsenso D.; Pedrero-Tome R.; Raimondi F.; Salome S.; Papaevangelou V.; Syridou G.; Rios-Barnes M.; Fortuny C.; Villaverde S.; De Vergas J.; Baquero-Artigao F.; Rodriguez-Molino P.; Frick M. A.; Alvarez-Vallejo B.; Saavedra-Lozano J.; Fougere Y.; Del Valle R.; Ara-Montojo F.; Foulon I.; Mignogna S.; Muga Zuriarrain O.; Lyall H.; Vives-Onos I.; Colino E.; Tsiatsiou O.; Moliner E.; Garofoli F.; Cuadrado I.; Blazquez-Gamero D.; Bringue Espuny X.; Sanchez Pintos P.; Isidro E. M. M.; Garcia Garcia M. J.; Corredera Sanchez A.; Illan M.; Cunarro A.; Medina Claros A. F.; Moliner Calderon E.; Carazo Gallego B.; Nunez Cuadros E.; Ferreras Antolin L.; Porta R.; Sota Busselo I.; Galan Del Rio P.; Pronzato Cuello F.; Dapena M.; Castells Vilella L.; Soto B.; Cuadrado Perez I.; Rincon Lopez E.; Duenas E.; Saavedra J.; Del Mar Santos M.; Grande Tejada A. M.; Del Castillo Navio E.; Navas A.; Agundez Reigosa B.; Tagarro Garcia A.; Perez Cid L.; De La Serna Martinez M.; Belen Jimenez A.; Calavia Garsaball O.; Martin Lopez E.; Carrasco J.; Baquero F.; Escosa L.; Del Rosal T.; Montesdeoca Melian A.; Vidal Moreso A.; Diez Martin R.; Pinillos R.; Barja Tur J.; Perez Garcia A.; Alvarez De Blas A.; Garrido Martinez-Salazar F.; Munoz Saa L.; Antonio Couceiro J.; Martinez Lorenzo R.; Beceiro J.; Ara F.; Encinas Pardilla M. B.; Sanchez Mateos M. F.; Alonso Ojembrana A.; Gutierrez Del Alamo C. F.; Rumbao Aguirre J. M.; Alvarez Breciano F.; Noguera Julian A.; Fortuny Guasch C.; Olabarrieta I.; Filgueira Posse A.; Herrero Perez S.; Llorente M.; Llana Martin I.; Alfonso Rodriguez O.; Soler Palacin P.; Terol Barrero P.; Montero Martin M.; Rodrigo C.; Carreras Abad C.; Nicolas Lopez M.; Coroleu Lletget W.; Garrote Llanos E.; Uriarte Gutierrez H.; Rementeria Radigales J. I.; Mensalvas Ruiz A. I.; Cervantes E.; Croche Santander B.; Fenoy M.; Bonil Martinez V.; Garcia Reymundo M.; Vaquerizo Vaquerizo V.; Reyes Millan B.; Araceli Hernandez D.; Romero Ramirez D.; Marin Cruz I.; Falcon L.; Guach B.; Sole L.; Cantero Garcia J.; Rico Pajares M.; Guillamo C.; Badillo Navarro K.; Sanz Rueda L.; Oliver A.; Malumbres M.; Gonzalez Bravo M. N.; Hawkins A.; Gonce A.; Salvia D.; Navarri D.; Ruiz Garcia M.; Costa Lima S.; Martin R.; Hassan Hassan E. H.; Pajkrt D.; Alexander E.; Motha R.; Selimaj V.; Kennedy V.; Oana Gabriela F. P.; Hilali A.; Haras M.; Kopsidas I.; Sophie Schaper A.; Fieterna-Sperling C.; Kruger R.; Stefansson V.; Freyne B.; Ferguson W.; Buttcher M.; Karaoglu Asrak H.; Rack-Hock A.; Thomas F.; Shah I.; Kenny J.; Cohen J.; Shah T.; Husada D.; Micol A.; Lombardi G.; Williams E.; Bamford A.; Elvegaard C.; Penner J.; Bhagwandas K.; Crane R.; Kadambari S.; Mendis S.; Pagarkar W.; Li X.; Gowin E.; Vergadi E.; Lopo Tuna M.; Abu Bakar A.; Reis Melo A.; Borgstein B.; Goniotakis I.; Jan W.; Lampada C.; Roilides E.; Charisi K.; Ohomoto De Morais C.; Guri A.; Mazur-Melewska K.; Bandi S.; Vossen A.; Kottapalli S.; Gardiner E.; Capozzi L.; Fitzgerald A.; McMaster P.; Holland S.; Waltson F.; Pocock L.; Jasmine M.; Scott S.; Wills S.; Lindsey B.; Douglas C.; David E.; Lees E.; Dominic K.; Pollard L.; Glikman D.; Sulik A.; Lewandowski D.; Toczylowski K.; Buciak A.; Majda-Stanislawska E.; Kaiser-Labusch P.; Jones L.; Fidler K.; Christie S.; Doherty C.; Spyridakou C.; Shackley F.; Armoush S.; Heath P.; Tan N.; Ibrahim S.; Tizzard S.; Storey S.; Drysdale S.; Walter S.; Janarthan S.; Kachramanoglou C.; Payne H.; Smyrnaios A.; Marisco C.; Grazia Capretti M.; Hector G.; Palasanthiran P.; Vernall R.; Meir M.; Mildred I.; Dhond K.; McCarthy K.; Almarzooqi M.; Evans J.; Muller J.; Pitcher J.; Tomlinson J.; Amaryl J.; Shears A.; Frattaroli P.; Sobowiec S.; Richmond V.; Ralph K.; Lindsey K.; Lanaghan C.; Langlands J.; O'Brien K.; Crawley R.; Manian A.; Alison K.; Smith C.; Hayman M.; Diaz F.; Parratt J.; Vanner N.; Jones B.; Kane J.; Chadwick R.; Keymeulen A.; Painoi P.; Sivakumaran S.; Parsonson V.; Sen C.; Kortsalioudaki C.; Nastouli E.; Martin J.; Wellings L.; Amor S.; Eisen S.; Tzaki A.; Mavridi A.; Loizou C.; Karagiannidou S.; Buxmann H.; Hafez L.; Alexe M.; Vogel T.; Smiskova D.; Bolchova J.; Schulze-Sturm U.; Ansary A.; Giacomet V.; Vila Bedmar S.; Villaverde Gonzalez S.; Prieto L.; Fernandez Cooke E.; Ramos Amador J. T.; Epalza C.; Moraleda C.; Shan A.; Soler J.; Rojo P. |
| Contributors: | D. Buonsenso; R. Pedrero-Tome; F. Raimondi; S. Salome; V. Papaevangelou; G. Syridou; M. Rios-Barne; C. Fortuny; S. Villaverde; J. De Verga; F. Baquero-Artigao; P. Rodriguez-Molino; M.A. Frick; B. Alvarez-Vallejo; J. Saavedra-Lozano; Y. Fougere; R. Del Valle; F. Ara-Montojo; I. Foulon; S. Mignogna; O. Muga Zuriarrain; H. Lyall; I. Vives-Ono; E. Colino; O. Tsiatsiou; E. Moliner; F. Garofoli; I. Cuadrado; D. Blazquez-Gamero; X. Bringue Espuny; P. Sanchez Pinto; E.M.M. Isidro; M.J. Garcia Garcia; A. Corredera Sanchez; M. Illan; A. Cunarro; A.F. Medina Claro; E. Moliner Calderon; B. Carazo Gallego; E. Nunez Cuadro; L. Ferreras Antolin; R. Porta; I. Sota Busselo; P. Galan Del Rio; F. Pronzato Cuello; M. Dapena; L. Castells Vilella; B. Soto; I. Cuadrado Perez; E. Rincon Lopez; E. Duena; J. Saavedra; M. Del Mar Santo; A.M. Grande Tejada; E. Del Castillo Navio; A. Nava; B. Agundez Reigosa; A. Tagarro Garcia; L. Perez Cid; M. De La Serna Martinez; A. Belen Jimenez; O. Calavia Garsaball; E. Martin Lopez; J. Carrasco; F. Baquero; L. Escosa; T. Del Rosal; A. Montesdeoca Melian; A. Vidal Moreso; R. Diez Martin; R. Pinillo; J. Barja Tur; A. Perez Garcia; A. Alvarez De Bla; F. Garrido Martinez-Salazar; L. Munoz Saa; J. Antonio Couceiro; R. Martinez Lorenzo; J. Beceiro; F. Ara; M.B. Encinas Pardilla; M.F. Sanchez Mateo; A. Alonso Ojembrana; C.F. Gutierrez Del Alamo; J.M. Rumbao Aguirre; F. Alvarez Breciano; A. Noguera Julian; C. Fortuny Guasch; I. Olabarrieta; A. Filgueira Posse; S. Herrero Perez; M. Llorente; I. Llana Martin; O. Alfonso Rodriguez; P. Soler Palacin; P. Terol Barrero; M. Montero Martin; C. Rodrigo; C. Carreras Abad; M. Nicolas Lopez |
| Publisher Information: | Lippincott Williams and Wilkins |
| Publication Year: | 2026 |
| Collection: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: | congenital; cytomegaloviru; late-onset hearing loss; Settore MEDS-20/A - Pediatria generale e specialistica |
| Description: | Background and aims: Children with congenital cytomegalovirus (cCMV) can develop late-onset sensorineural hearing loss (LO-SNHL). In this study, we aim to assess the characteristics and predictors of LO-SNHL in infants with cCMV having normal hearing at the first neonatal assessment. Methods: A retrospective study within the European Registry of Children with cCMV (www.ccmvnet.org) was performed. Included children had cCMV and a normal first audiological assessment by Auditory Brainstem Response (ABR). Late-onset hearing loss (LO-SNHL) is defined as the presence of sensorineural hearing loss after an initial normal hearing test. Hearing evaluation was performed at birth, at 6 months of age, and at least annually up to 6 years of age. Results: Seven hundred twenty-one children with normal audiological tests at birth were included, and 47/721 (6.5%) developed LO-SNHL. LO-SNHL was diagnosed at a range of 4-65 months of age [median (IQR) age: 34.3 (15.1-48.7) months]. Children with LO-SNHL had a higher proportion of abnormalities on physical examination at birth (45.7% vs. 20.8%; P < 0.001): petechiae (17.4% vs. 6.0%; P = 0.008), splenomegaly (8.7% vs. 2.3%; P = 0.031), hepatomegaly (13% vs. 2.9%; P = 0.001), microcephaly (15.2% vs. 4.5%; P = 0.005) and small for gestational age (21.7% vs. 8.3% P = 0.005). Children with LO-SNHL showed lower platelet count at birth [177500.0 (88750.0-261250.0)/μL vs. 243500.0 (173000.0-304000.0)/μL; P = 0.012], and higher blood viral load at birth [3.7 log (3.3-4.4) vs. 3.4 log (2.7-3.9) IU/mL; P = 0.013] and had more frequent white matter involvement (27.7% vs. 14.7%; P = 0.03) and ventriculomegaly (20.7% vs. 4.6%; P = 0.001) on birth magnetic resonance imaging. Overall, symptomatic children at birth showed a higher risk of developing LO-SNHL than asymptomatic children (32/317, 10.1%, vs. 15/404, 3.7%; P < 0.0001). Among asymptomatic children, only 0.3% developed severe or profound LO-SNHL in the best ear. In multivariate logistic regression analysis, ventriculomegaly [odds ... |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | volume:45; issue:1; firstpage:1; lastpage:10; numberofpages:10; journal:THE PEDIATRIC INFECTIOUS DISEASE JOURNAL; https://hdl.handle.net/2434/1209515 |
| DOI: | 10.1097/inf.0000000000004960 |
| Availability: | https://hdl.handle.net/2434/1209515; https://doi.org/10.1097/inf.0000000000004960 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.5470B283 |
| Database: | BASE |