| Title: |
Clinical management and disease-modifying treatment for amyotrophic lateral sclerosis in African hospital centers: the TROPALS study |
| Authors: |
Luna, Jaime; Jost, Jeremy; Diagana, Mouhamadou; Ait Aissa, Leila; Tazir, Meriem; Ali Pacha, Lamia; Kacem, Imen; Gouider, Riadh; Henning, Franclo; Basse, Anna; Cisse, Ousmane; Balogou, Aa Koffi; Kombate, Damelan; Agbetou, Mendinatou; Houinato, Dismand Stephan; Gnonlonfoun, Dieu Donné; Millogo, Athanase; Agba, Thierry; Belo, Mouftao; Sengxeu, Noudy; Hamidou, Bello; Preux, Pierre-Marie; Benoit, Marin; Couratier, Philippe |
| Contributors: |
Neuroépidémiologie Tropicale (NET); CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST); Université de Limoges (UNILIM)-Université de Limoges (UNILIM); Epidémiologie des Maladies Chroniques en zone tropicale (EpiMaCT); Institut de Recherche pour le Développement (IRD)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-OmégaHealth (ΩHealth); Service de Pharmacie Centrale CHU Limoges; CHU Limoges; Service de Neurologie, C.H.U Mustapha Bacha, Place du 1er Mai, 16000 Alger, Algeria; Hopital de Razi - Razi Hospital Tunis; Stellenbosch University (SU); CHNU Fann Dakar; Service de Neurologie, CHU Campus Université de Lomé; Service de Neurologie, CHU Campus Université de Lomé-Service de Neurologie, CHU Campus Université de Lomé; Centre National Hospitalier Universitaire Hubert K. Maga de Cotonou (CNHU-HKM); Laboratory of Chronic and Neurological Diseases Epidemiology (LEMACEN); Université d’Abomey-Calavi = University of Abomey Calavi (UAC); Université Joseph Ki-Zerbo de Ouagadougou = University of Ouagadougou (UJZK); Université de Lomé Togo; Plate forme de bioinformatique et biostatistique (CEBIMER); Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST); Service de Neurologie CHU Limoges |
| Source: |
ISSN: 2167-8421 ; Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration ; https://unilim.hal.science/hal-03339802 ; Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2022, 23 (3-4), pp.279-283. ⟨10.1080/21678421.2021.1961806⟩. |
| Publisher Information: |
CCSD; Taylor & Francis |
| Publication Year: |
2022 |
| Collection: |
Université de Limoges: HAL |
| Subject Terms: |
riluzole; management; availability; affordability; Amyotrophic lateral sclerosis; Africa; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| Description: |
International audience ; Objective: To assess the availability of health workers and medications for clinical management of amyotrophic lateral sclerosis (ALS) in African hospital centers. Availability and affordability analyses of disease-modifying treatments were performed. Methods: A multicenter observational study involving African hospitals was conducted. A standard questionnaire was developed based on the European Federation of the Neurological Societies (EFNS) guidelines. We collected data on multidisciplinary care and availability of medicines. The availability and affordability were evaluated according to the WHO guidelines. Results: Nine hospital centers from eight African countries participated. We observed a low degree of implementation of multidisciplinary care in ALS management. Riluzole was only available in centers from South Africa, Senegal, Tunisia, and Togo. This treatment was unaffordable and the adjusted price was highly variable among countries. The cost of riluzole was partly or fully covered by patients, which implies a substantial economic burden. Conclusion: Our findings strengthen the need to promote multidisciplinary care in the clinical management of ALS in Africa. Disease-modifying medication should be both available and affordable. Local and international collaboration is needed to improve ALS health care access in Africa. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/34459327; PUBMED: 34459327 |
| DOI: |
10.1080/21678421.2021.1961806 |
| Availability: |
https://unilim.hal.science/hal-03339802; https://doi.org/10.1080/21678421.2021.1961806 |
| Accession Number: |
edsbas.5498487D |
| Database: |
BASE |