| Title: |
Analysis of prognostic factors in COVID-19 hospitalized patients. an italian single-center case-control study |
| Authors: |
Concistrè, A; Petramala, L; Pugliano, C L; Celi, M; Vinci, F; Assanto, E; Barchetta, I; Perrone, E P; Rella, S; Iannazzo, F; Angheloni, A; Coraggio, L; Di Rienzo, F; Maggi, D; Circosta, F; Galardo, G; Muscaritoli, M; Letizia, C |
| Contributors: |
Concistrè, A; Petramala, L; Pugliano, C L; Celi, M; Vinci, F; Assanto, E; Barchetta, I; Perrone, E P; Rella, S; Iannazzo, F; Angheloni, A; Coraggio, L; Di Rienzo, F; Maggi, D; Circosta, F; Galardo, G; Muscaritoli, M; Letizia, C |
| Publisher Information: |
Verduci Editore s.r.l. |
| Publication Year: |
2023 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
COVID-19; SARS-CoV-2; prediction; lactic dehydrogenase; prognosi; ICU; hospitalization; NIV; C reactive protein; corticosteroid therapy |
| Description: |
OBJECTIVE: COVID-19 clinical presentation ranges from asymptomatic infec-tion to an inflammatory cytokine storm with multi-organ failure and fatal outcomes. The identification of high-risk patients for severe disease is crucial to plan an early treatment and intensive follow-up. We aimed to investi-gate negative prognostic factors in a group of patients hospitalized for COVID-19. PATIENTS AND METHODS: 181 patients (90 men and 91 women, mean age 66.56 +/- 13.53 years) were enrolled. Each patient received a work-up in-cluding medical history, clinical examination, arte-rial blood gas analysis, laboratory blood tests, fea-sible ventilatory support required during hospital stay, intensive care setting required, duration of illness and length of hospital stay (> or < 25 days). For the assessment of the severity of COVID-19, three main indicators were considered: 1) the in-tensive care unit (ICU) admission 2) the hospital-ization length > 25 days; 3) the need of non-inva-sive ventilation (NIV). RESULTS: The independent risk factor associ-ated with the ICU admission were lactic dehydro-genase elevation (p=0.046), C reactive protein elevation (p=0.014) at hospital admission and di-rect oral anticoagulant home therapy (p=0.048); for hospital length > 25 days: early corticosteroid therapy (p=0.035); for NIV treatment: ferritin ele-vation at hospital admission (p=0.006). CONCLUSIONS: The presence of the above factors may be useful to identify patients at high risk of developing a severe COVID-19 that need an early treatment and intensive follow-up. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36808370; info:eu-repo/semantics/altIdentifier/wos/WOS:000943329300023; volume:27; issue:3; firstpage:1207; lastpage:1221; numberofpages:15; journal:EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES; https://hdl.handle.net/11573/1687685 |
| DOI: |
10.26355/eurrev_202302_31232 |
| Availability: |
https://hdl.handle.net/11573/1687685; https://doi.org/10.26355/eurrev_202302_31232 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.54C5170 |
| Database: |
BASE |