The Gene Ontology resource: enriching a GOld mine
| Title: | The Gene Ontology resource: enriching a GOld mine |
|---|---|
| Authors: | Carbon S; Douglass E; Good BM; Unni DR; Harris NL; Mungall CJ; Basu S; Chisholm RL; Dodson RJ; Hartline E; Fey P; Thomas PD; Albou LP; Ebert D; Kesling MJ; Mi HY; Muruganujan A; Huang XS; Mushayahama T; LaBonte SA; Siegele DA; Antonazzo G; Attrill H; Brown NH; Garapati P; Marygold SJ; Trovisco V; Dos Santos G; Falls K; Tabone C; Zhou PL; Goodman JL; Strelets VB; Thurmond J; Garmiri P; Ishtiaq R; Rodriguez-Lopez M; Acencio ML; Kuiper M; Laegreid A; Logie C; Lovering RC; Kramarz B; Saverimuttu SCC; Pinheiro SM; Gunn H; Su RZ; Thurlow KE; Chibucos M; Giglio M; Nadendla S; Munro J; Jackson R; Duesbury MJ; Del-Toro N; Meldal BHM; Paneerselvam K; Perfetto L; Porras P; Orchard S; Shrivastava A; Chang HY; Finn RD; Mitchell AL; Rawlings ND; Richardson L; Sangrador-Vegas A; Blake JA; Christie KR; Dolan ME; Drabkin HJ; Hill DP; Ni L; Sitnikov DM; Harris MA; Oliver SG; Rutherford K; Wood V; Hayles J; Bahler J; Bolton ER; De Pons JL; Dwinell MR; Hayman GT; Kaldunski ML; Kwitek AE; Laulederkind SJF; Plasterer C; Tutaj MA; Vedi M; Wang SJ; D'Eustachio P; Matthews L; Balhoff JP; Aleksander SA; Alexander MJ; Cherry JM; Engel SR; Gondwe F; Karra K; Miyasato SR; Nash RS; Simison M; Skrzypek MS; Weng S; Wong ED; Feuermann M; Gaudet P; Morgat A; Bakker E; Berardini TZ; Reiser L; Subramaniam S; Huala E; Arighi CN; Auchincloss A; Axelsen K; Argoud-Puy G; Bateman A; Blatter MC; Boutet E; Bowler E; Breuza L; Bridge A; Britto R; Bye-A-Jee H; Casas CC; Coudert E; Denny P; Estreicher A; Famiglietti ML; Georghiou G; Gos A; Gruaz-Gumowski N; Hatton-Ellis E; Hulo C; Ignatchenko A; Jungo F; Laiho K; Le Mercier P; Lieberherr D; Lock A; Lussi Y; MacDougall A; Magrane M; Martin MJ; Masson P; Natale DA; Hyka-Nouspikel N; Pedruzzi I; Pourcel L; Poux S; Pundir S; Rivoire C; Speretta E; Sundaram S; Tyagi N; Warner K; Zaru R; Wu CH; Diehl AD; Chan JN; Grove C; Lee RYN; Muller HM; Raciti D; Van Auken K; Sternberg PW; Berriman M; Paulini M; Howe K; Gao S; Wright A; Stein L; Howe DG; Toro S; Westerfield M; Jaiswal P; Cooper L; Elser J |
| Contributors: | Carbon, S; Douglass, E; Good, Bm; Unni, Dr; Harris, Nl; Mungall, Cj; Basu, S; Chisholm, Rl; Dodson, Rj; Hartline, E; Fey, P; Thomas, Pd; Albou, Lp; Ebert, D; Kesling, Mj; Mi, Hy; Muruganujan, A; Huang, X; Mushayahama, T; Labonte, Sa; Siegele, Da; Antonazzo, G; Attrill, H; Brown, Nh; Garapati, P; Marygold, Sj; Trovisco, V; Dos Santos, G; Falls, K; Tabone, C; Zhou, Pl; Goodman, Jl; Strelets, Vb; Thurmond, J; Garmiri, P; Ishtiaq, R; Rodriguez-Lopez, M; Acencio, Ml; Kuiper, M; Laegreid, A; Logie, C; Lovering, Rc; Kramarz, B; Saverimuttu, Scc; Pinheiro, Sm; Gunn, H; Su, Rz; Thurlow, Ke; Chibucos, M; Giglio, M; Nadendla, S; Munro, J; Jackson, R; Duesbury, Mj; Del-Toro, N; Meldal, Bhm; Paneerselvam, K; Perfetto, L; Porras, P; Orchard, S; Shrivastava, A; Chang, Hy; Finn, Rd; Mitchell, Al; Rawlings, Nd; Richardson, L; Sangrador-Vegas, A; Blake, Ja; Christie, Kr; Dolan, Me; Drabkin, Hj; Hill, Dp; Ni, L; Sitnikov, Dm; Harris, Ma; Oliver, Sg; Rutherford, K; Wood, V; Hayles, J; Bahler, J; Bolton, Er; De Pons, Jl; Dwinell, Mr; Hayman, Gt; Kaldunski, Ml; Kwitek, Ae; Laulederkind, Sjf; Plasterer, C; Tutaj, Ma; Vedi, M; Wang, Sj; D'Eustachio, P; Matthews, L; Balhoff, Jp; Aleksander, Sa; Alexander, Mj; Cherry, Jm; Engel, Sr; Gondwe, F; Karra, K |
| Publisher Information: | Oxford University Press |
| Publication Year: | 2021 |
| Collection: | Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: | Gene Ontology; Data curation; GO-CAMs |
| Description: | The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The new GO-CAM annotation framework was notably improved, and we formalized the model with a computational schema to check and validate the rapidly increasing repository of 2838 GO-CAMs. In addition, we describe the impacts of several collaborations to refine GO and report a 10% increase in the number of GO annotations, a 25% increase in annotated gene products, and over 9,400 new scientific articles annotated. As the project matures, we continue our efforts to review older annotations in light of newer findings, and, to maintain consistency with other ontologies. As a result, 20 000 annotations derived from experimental data were reviewed, corresponding to 2.5% of experimental GO annotations. The website (http://geneontology.org) was redesigned for quick access to documentation, downloads and tools. To maintain an accurate resource and support traceability and reproducibility, we have made available a historical archive covering the past 15 years of GO data with a consistent format and file structure for both the ontology and annotations. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/33290552; info:eu-repo/semantics/altIdentifier/wos/WOS:000608437800042; volume:49; issue:D1; firstpage:325; lastpage:334; numberofpages:10; journal:NUCLEIC ACIDS RESEARCH; https://hdl.handle.net/11573/1660163 |
| DOI: | 10.1093/nar/gkaa1113 |
| Availability: | https://hdl.handle.net/11573/1660163; https://doi.org/10.1093/nar/gkaa1113 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.55044996 |
| Database: | BASE |