| Title: |
Serum and macular response to carotenoid-enriched egg supplementation in human subjects: the Egg Xanthophyll Intervention clinical Trial (EXIT) |
| Authors: |
Kelly, David; Nolan, John M.; Howard, Alan N.; Stack, Jim; Akuffo, Kwadwo O.; Moran, Rachel; Thurnham, David I.; Dennison, Jessica; Meagher, Katherine A.; Beatty, Stephen |
| Source: |
British Journal of Nutrition ; volume 117, issue 1, page 108-123 ; ISSN 0007-1145 1475-2662 |
| Publisher Information: |
Cambridge University Press (CUP) |
| Publication Year: |
2017 |
| Description: |
The macular carotenoids lutein (L), zeaxanthin (Z) and meso -zeaxanthin (MZ) accumulate at the macula, where they are collectively referred to as macular pigment (MP). Augmentation of this pigment, typically achieved through diet and supplementation, enhances visual function and protects against progression of age-related macular degeneration. However, it is known that eggs are a rich dietary source of L and Z, in a highly bioavailable matrix. In this single-blind placebo-controlled study, L- and MZ-enriched eggs and control non-enriched eggs were fed to human subjects (mean age 41 and 35 years, respectively) over an 8-week period, and outcome measures included MP, visual function and serum concentrations of carotenoids and cholesterol. Serum carotenoid concentrations increased significantly in control and enriched egg groups, but to a significantly greater extent in the enriched egg group ( P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1017/s0007114516003895 |
| Availability: |
https://doi.org/10.1017/s0007114516003895; https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114516003895 |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.55266247 |
| Database: |
BASE |