| Title: |
Exercise-intensity dependent variability in rates of aerobic metabolism is related to genetic aspects of muscle-type associated lactate transport in tactical athletes |
| Authors: |
Flück, Martin; Giraud, Marie-Noëlle; Protte, Christian; Dössegger, Alain |
| Source: |
Current Issues in Sport Science (CISS); Bd. 11 Nr. 2 (2026): 17th Annual Conference of the Swiss Society of Sport Science (4S), February 11 and 12, 2026, at University of Fribourg - Sports and Nutrition: Performance and Health Benefits. Book of Abstracts.; 046 ; Current Issues in Sport Science (CISS); Vol. 11 No. 2 (2026): 17th Annual Conference of the Swiss Society of Sport Science (4S), February 11 and 12, 2026, at University of Fribourg - Sports and Nutrition: Performance and Health Benefits. Book of Abstracts.; 046 ; 2414-6641 |
| Publisher Information: |
Bern Open Publishing (BOP) |
| Publication Year: |
2026 |
| Collection: |
BOP Serials (Bern Open Publishing, University of Bern) |
| Subject Terms: |
personalized exercise; genetic; respiration; testing; lactate |
| Description: |
Introduction: Lactate accumulation during exercise marks a shift toward anaerobic glucose metabolism when oxygen-dependent substrate metabolization cannot sustain repeated contraction. Thereby it may influence perfusion via dilation of resistance vessels and modulate ventilation through chemoreceptor activity, potentially contributing to interindividual variability in respiration, perfusion, and pulmonary oxygen uptake at metabolic thresholds. Genetic mechanisms further shape these processes: monocarboxylate transporter 1 (MCT1) enables lactate transport between fibers and tissues, while angiotensin converting enzyme (ACE) affects cardiovascular adaptation and metabolite redistribution (Gasser et al., 2024). Lactate accumulation at ventilatory thresholds correlates with haemoglobin deoxygenation in active muscle (Perrey et al., 2024; Batterson et al., 2023). These insights suggest genotype‑dependent regulation of lactate handling and aerobic fitness may drive variability in muscle oxygenation and systemic metabolism at exercise thresholds. Purpose: To investigate whether the MCT1 genotype influences relative rates of muscle and systemic aerobic metabolism at ventilatory thresholds (VT1, VT2) during exhaustive running, in interaction with ACE-ID genotype and aerobic fitness. Methods: A cohort of 169 Caucasian tactical athletes (27.7 ± 7.3 years; 179.2 ± 7.2 cm; 78.7 ± 10.2 kg) performed ramped, loaded treadmill exercise to exhaustion (Flück et al 2024). Aerobic metabolism was assessed via ergospirometry and near infrared spectroscopy in knee extensor (vastus lateralis, VAS) and ankle extensor (gastrocnemius medialis, GAS). Maximal oxygen uptake (VO₂max) and ventilatory thresholds were determined, with aerobic fitness defined as ≥50 mL O₂·min⁻¹·kg⁻¹. Genotyping of MCT1 (rs1049434) and ACE-ID (rs1799752) was performed using PCR. Effects of genotype, fitness, and muscle type were analyzed with ANOVA at a 5%-threshold. Results: Athletes demonstrated exceptional aerobic performance (510.4 ± 76.9 W) and VO₂max (4.2 ± ... |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| DOI: |
10.36950/2026.2ciss046 |
| Availability: |
https://ciss-journal.org/article/view/13355; https://doi.org/10.36950/2026.2ciss046 |
| Rights: |
Copyright (c) 2026 Martin Flück, Marie-Noëlle Giraud, Christian Protte, Alain Dössegger ; https://creativecommons.org/licenses/by/4.0 |
| Accession Number: |
edsbas.553A05FD |
| Database: |
BASE |