| Title: |
Decline in cognition from mid-life improves specificity of mini-mental state examination:diagnostic test accuracy in Caerphilly Prospective Study (CaPs) |
| Authors: |
Creavin, Sam T; Fish, Mark; Bayer, A; Ben-Shlomo, Yoav; Gallacher, J |
| Source: |
Creavin, S T, Fish, M, Bayer, A, Ben-Shlomo, Y & Gallacher, J 2022, 'Decline in cognition from mid-life improves specificity of mini-mental state examination : diagnostic test accuracy in Caerphilly Prospective Study (CaPs)', Journal of Alzheimer's Disease, vol. 89, no. 4, pp. 1241-1248. https://doi.org/10.3233/JAD-220345 |
| Publication Year: |
2022 |
| Collection: |
University of Bristol: Bristol Reserach |
| Description: |
Background: The merit of using baseline cognitive assessments in mid-life to help interpret cross-sectional cognitive tests scores in later life is uncertain. We evaluated how accuracy for diagnosing dementia is enhanced by comparing cross-sectional results to a midlife measure. Method: Cohort study of 2,512 men with repeated measures of Mini Mental State Examination (MMSE) over approximately 10 years. Index test MMSE at threshold of 24 indicating normal, as a cross-sectional measure and in combination with decline in MMSE score from mid-life. Reference standard consensus clinical diagnosis of dementia by two clinicians according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). Results: 1,150 men participated at phase 4 of whom 75 had dementia. A cross-sectional MMSE alone produced a sensitivity of 60% (50% to 70%) and specificity 95% (94% to 97%) with a threshold of ≥ 24 points indicating normal. For lower-scoring men in late life, with cross sectional scores of |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35988222; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/1983/77703ede-fb9c-4529-b499-6abf12f2b963 |
| DOI: |
10.3233/JAD-220345 |
| Availability: |
https://hdl.handle.net/1983/77703ede-fb9c-4529-b499-6abf12f2b963; https://research-information.bris.ac.uk/en/publications/77703ede-fb9c-4529-b499-6abf12f2b963; https://doi.org/10.3233/JAD-220345; https://research-information.bris.ac.uk/ws/files/332411504/2022_6_2_Cognitive_decline_Caps_Sam_Creavin_all.pdf |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.5544667F |
| Database: |
BASE |