| Title: |
A prognostic model to predict survival after 6 months of ruxolitinib in patients with myelofibrosis |
| Authors: |
Maffioli M.; Mora B.; Ball S.; Iurlo A.; Elli E. M.; Finazzi M. C.; Polverelli N.; Rumi E.; Caramella M.; Carraro M. C.; D'Adda M.; Molteni A.; Sissa C.; Lunghi F.; Vismara A.; Ubezio M.; Guidetti A.; Caberlon S.; Anghilieri M.; Komrokji R.; Cattaneo D.; Della Porta M. G.; Giorgino T.; Bertu L.; Brociner M.; Kuykendall A.; Passamonti F. |
| Contributors: |
Maffioli, M.; Mora, B.; Ball, S.; Iurlo, A.; Elli, E. M.; Finazzi, M. C.; Polverelli, N.; Rumi, E.; Caramella, M.; Carraro, M. C.; D'Adda, M.; Molteni, A.; Sissa, C.; Lunghi, F.; Vismara, A.; Ubezio, M.; Guidetti, A.; Caberlon, S.; Anghilieri, M.; Komrokji, R.; Cattaneo, D.; Della Porta, M. G.; Giorgino, T.; Bertu, L.; Brociner, M.; Kuykendall, A.; Passamonti, F. |
| Publication Year: |
2022 |
| Collection: |
IRInSubria - Institutional Repository Insubria (Università degli Studi dell’Insubria) |
| Subject Terms: |
Human; Nitrile; Prognosi; Pyrazole; Pyrimidine; Retrospective Studie; Primary Myelofibrosis |
| Description: |
Ruxolitinib (RUX) is extensively used in myelofibrosis (MF). Despite its early efficacy, most patients lose response over time and, after discontinuation, have a worse overall survival (OS). Currently, response criteria able to predict OS in RUX-treated patients are lacking, leading to uncertainty regarding the switch to second-line treatments. In this study, we investigated predictors of survival collected after 6 months of RUX in 209 MF patients participating in the real-world ambispective observational RUXOREL-MF study (NCT03959371). Multivariable analysis identified the following risk factors: (1) RUX dose,20 mg twice daily at baseline, months 3 and 6 (hazard ratio [HR], 1.79; 95% confidence interval [CI], 1.07-3.00; P 5.03), (2) palpable spleen length reduction from baseline #30% at months 3 and 6 (HR, 2.26; 95% CI, 1.40-3.65; P 5.0009), (3) red blood cell (RBC) transfusion need at months 3 and/or 6 (HR, 1.66; 95% CI, 0.95-2.88; P 5.07), and (4) RBC transfusion need at all time points (ie, baseline and months 3 and 6; HR, 2.32; 95% CI, 1.19-4.54; P 5.02). Hence, we developed a prognostic model, named Response to Ruxolitinib After 6 Months (RR6), dissecting 3 risk categories: low (median OS, not reached), intermediate (median OS, 61 months; 95% CI, 43-80), and high (median OS, 33 months; 95% CI, 21-50). The RR6 model was validated and confirmed in an external cohort comprised of 40 MF patients. In conclusion, the RR6 prognostic model allows for the early identification of RUX-treated MF patients with impaired survival who might benefit from a prompt treatment shift. |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35130339; info:eu-repo/semantics/altIdentifier/wos/WOS:000791841500005; volume:6; issue:6; firstpage:1855; lastpage:1864; numberofpages:10; journal:BLOOD ADVANCES; https://hdl.handle.net/11383/2143458 |
| DOI: |
10.1182/bloodadvances.2021006889 |
| Availability: |
https://hdl.handle.net/11383/2143458; https://doi.org/10.1182/bloodadvances.2021006889 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.556788E8 |
| Database: |
BASE |