| Title: |
Albuminuria Testing in Hypertension and Diabetes: An Individual-Participant Data Meta-Analysis in a Global Consortium |
| Authors: |
Shin, JI; Chang, AR; Grams, ME; Coresh, J; Ballew, SH; Surapaneni, A; Matsushita, K; Bilo, HJG; Carrero, JJ; Chodick, G; Daratha, KB; Jassal, SK; Nadkarni, GN; Nelson, RG; Nowak, C; Stempniewicz, N; Sumida, K; Traynor, JP; Woodward, M; Sang, Y; Gansevoort, RT |
| Source: |
urn:ISSN:0194-911X ; urn:ISSN:1524-4563 ; Hypertension, 78, 4, 1042-1052 |
| Publisher Information: |
Wolters Kluwer |
| Publication Year: |
2021 |
| Collection: |
UNSW Sydney (The University of New South Wales): UNSWorks |
| Subject Terms: |
32 Biomedical and Clinical Sciences; 3201 Cardiovascular Medicine and Haematology; 3202 Clinical Sciences; Hypertension; Diabetes; Cardiovascular; Metabolic and endocrine; Adult; Aged; Albuminuria; Creatinine; Diabetes Mellitus; Glomerular Filtration Rate; Humans; Middle Aged; Renal Insufficiency; Chronic; blood pressure; kidney; prevalence risk; CKD Prognosis Consortium; anzsrc-for: 32 Biomedical and Clinical Sciences; anzsrc-for: 3201 Cardiovascular Medicine and Haematology; anzsrc-for: 3202 Clinical Sciences; anzsrc-for: 1102 Cardiorespiratory Medicine and Haematology; anzsrc-for: 1103 Clinical Sciences; anzsrc-for: 1117 Public Health and Health Services |
| Description: |
Albuminuria is an under-recognized component of chronic kidney disease definition, staging, and prognosis. Guidelines, particularly for hypertension, conflict on recommendations for urine albumin-to-creatinine ratio (ACR) measurement. Separately among 1 344 594 adults with diabetes and 2 334 461 nondiabetic adults with hypertension from the chronic kidney disease Prognosis Consortium, we assessed ACR testing, estimated the prevalence and incidence of ACR ≥30 mg/g and developed risk models for ACR ≥30 mg/g. The ACR screening rate (cohort range) was 35.1% (12.3%-74.5%) in diabetes and 4.1% (1.3%-20.7%) in hypertension. Screening was largely unrelated to the predicted risk of prevalent albuminuria. The median prevalence of ACR ≥30 mg/g across cohorts was 32.1% in diabetes and 21.8% in hypertension. Higher systolic blood pressure was associated with a higher prevalence of albuminuria (odds ratio [95% CI] per 20 mm Hg in diabetes, 1.50 [1.42-1.60]; in hypertension, 1.36 [1.28-1.45]). The ratio of undetected (due to lack of screening) to detected ACR ≥30 mg/g was estimated at 1.8 in diabetes and 19.5 in hypertension. Among those with ACR |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://hdl.handle.net/1959.4/107374; https://doi.org/10.1161/HYPERTENSIONAHA.121.17323 |
| DOI: |
10.1161/HYPERTENSIONAHA.121.17323 |
| Availability: |
https://hdl.handle.net/1959.4/107374; https://unsworks.unsw.edu.au/bitstreams/0f5b6703-9b51-4f9b-9590-094d96a42429/download; https://doi.org/10.1161/HYPERTENSIONAHA.121.17323 |
| Rights: |
open access ; https://purl.org/coar/access_right/c_abf2 ; CC-BY ; https://creativecommons.org/licenses/by/4.0/ ; free_to_read |
| Accession Number: |
edsbas.558E949D |
| Database: |
BASE |