| Title: |
Long-term motor and cognitive outcome of Deep Brain Stimulation in GBA-PD: the Italian PARKNET study |
| Authors: |
Avenali, M.; Artusi, C. A.; Cilia, R.; Giannini, G.; Cuconato, G.; Albanese, A.; Andreasi, N. G.; Antenucci, P.; Antonini, A.; Avanzino, L.; Baldelli, L.; Bentivoglio, A. R.; Bove, F.; Bozzali, M.; Calandra-Buonaura, G.; Cani, I.; Carelli, V.; Cavallieri, F.; Cocco, A.; Cogiamanian, F.; Colucci, F.; Cortelli, P.; De Biase, A.; Di Biasio, F.; Di Fonzo, A.; D?Onofrio, V.; Eleopra, R.; Elia, A. E.; Fioravanti, V.; Genovese, D.; Guerra, A.; Imarisio, A.; Ledda, C.; Liccari, M.; Longo, C.; Lopiano, L.; Malaguti, M. C.; Malito, R.; Mameli, F.; Marino, S.; Minardi, R.; Mitrotti, P.; Monfrini, E.; Pacchetti, C.; Piano, C.; Rispoli, V.; Rizzone, M. G.; Romito, L. M.; Sambati, L.; Sensi, M.; Sorbera, C.; Spagnolo, F.; Tassorelli, C.; Valentino, F.; Valzania, F.; Zangaglia, R.; Zibetti, M.; Valente, E. M. |
| Contributors: |
Avenali, M.; Artusi, C. A.; Cilia, R.; Giannini, G.; Cuconato, G.; Albanese, A.; Andreasi, N. G.; Antenucci, P.; Antonini, A.; Avanzino, L.; Baldelli, L.; Bentivoglio, A. R.; Bove, F.; Bozzali, M.; Calandra-Buonaura, G.; Cani, I.; Carelli, V.; Cavallieri, F.; Cocco, A.; Cogiamanian, F.; Colucci, F.; Cortelli, P.; De Biase, A.; Di Biasio, F.; Di Fonzo, A.; D?onofrio, V.; Eleopra, R.; Elia, A. E.; Fioravanti, V.; Genovese, D.; Guerra, A.; Imarisio, A.; Ledda, C.; Liccari, M.; Longo, C.; Lopiano, L.; Malaguti, M. C.; Malito, R.; Mameli, F.; Marino, S.; Minardi, R.; Mitrotti, P.; Monfrini, E.; Pacchetti, C.; Piano, C.; Rispoli, V.; Rizzone, M. G.; Romito, L. M.; Sambati, L.; Sensi, M.; Sorbera, C.; Spagnolo, F.; Tassorelli, C.; Valentino, F.; Valzania, F.; Zangaglia, R.; Zibetti, M.; Valente, E. M. |
| Publication Year: |
2024 |
| Collection: |
Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| Subject Terms: |
Long-Term Motor; Cognitive Outcome; Deep Brain Stimulation; Parkinson Disease; GBA1 |
| Description: |
Background and Objectives Deep brain stimulation (DBS) is an established treatment for Parkinson disease (PD). In patients carrying GBA1 variants (GBA-PD), concerns persist that DBS may accelerate cognitive decline. This study investigated the potential additive effects of GBA1 genotype and DBS on long-term motor and nonmotor outcomes. Methods This multicenter retrospective, controlled, Italian study included 3 groups: DBS-treated PD patients either carrying or noncarrying GBA1 variants (DBS-nonGBA-PD and DBS-GBA-PD) and GBA-PD patients who fulfilled DBS criteria but eventually were not operated. As secondary aims, we assessed the clinical outcomes of DBS-GBA-PD stratified by GBA1 variant classes and by different DBS targets. Cognitive, motor, and other nonmotor features were collected at baseline and after 1, 3 and, when available, 5 years. Between-group comparisons used χ 2 and Kruskal-Wallis tests with Bon- ferroni correction. Longitudinal changes were analyzed with linear mixed-effects models. Subgroup analyses were performed by GBA1 variant class and DBS target. Results A total of 615 participants were included: 430 DBS-nonGBA-PD (age 57.4 ± 7.7 years, 32% female), 109 DBS-GBA-PD (age 53.5 ± 8.4 years, 38% female), and 76 nonDBS-GBA-PD (age 57.7 ± 8.1 years, 37% female). At baseline, groups were largely matched for clinical features. Longitudinally, both DBS groups showed marked motor improvement (dyskinesias, on-off phenomenon, and wearing-off, all p vs T0 < 0.001), a benefit which was absent in nonDBS-GBA-PD. At 5 years, dementia occurred more frequently in DBS-GBA-PD and nonDBS-GBA-PD compared with DBS-nonGBA-PD (25.5% vs 36.8% vs 10.8%, p < 0.001). Hallucinations and urinary problems increased in both GBA-PD groups than nonGBA-PD (p-between |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
firstpage:1; lastpage:16; numberofpages:16; journal:NEUROLOGY; https://hdl.handle.net/11562/1181286 |
| DOI: |
10.1101/2024.12.23.24319546 |
| Availability: |
https://hdl.handle.net/11562/1181286; https://doi.org/10.1101/2024.12.23.24319546 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Dominio pubblico ; license uri:http://creativecommons.org/publicdomain/zero/1.0/ |
| Accession Number: |
edsbas.559956D2 |
| Database: |
BASE |