| Title: |
The Effect of Semaglutide on Mortality and COVID-19–Related Deaths: An Analysis From the SELECT Trial |
| Authors: |
Scirica B. M.; Lincoff A. M.; Lingvay I.; Bogdanski P.; Buscemi S.; Colhoun H.; Craciun A. E.; Ezhov M.; Hardt-Lindberg S.; Kleist Jeppesen O.; Matos A. L. S. A.; Node K.; Schiele F.; Toplak H.; van Beek A.; Weeke P. E.; Wiviott S. D.; Deanfield J.; Ryan D. |
| Contributors: |
Scirica B.M.; Lincoff A.M.; Lingvay I.; Bogdanski P.; Buscemi S.; Colhoun H.; Craciun A.E.; Ezhov M.; Hardt-Lindberg S.; Kleist Jeppesen O.; Matos A.L.S.A.; Node K.; Schiele F.; Toplak H.; van Beek A.; Weeke P.E.; Wiviott S.D.; Deanfield J.; Ryan D. |
| Publication Year: |
2024 |
| Collection: |
IRIS Università degli Studi di Palermo |
| Subject Terms: |
obesity; semaglutide; cardiovascular events; covid-19; mortality; Settore MEDS-08/A - Endocrinologia; Settore MEDS-08/C - Scienza dell'alimentazione e delle tecniche dietetiche applicate; Settore MEDS-05/A - Medicina interna |
| Description: |
BACKGROUND Patients with overweight and obesity are at increased risk of death from multiple causes, including cardiovascular (CV) death, with few therapies proven to reduce the risk. OBJECTIVES This study sought to assess the effect of semaglutide 2.4 mg on all-cause death, CV death, and non-CV death, including subcategories of death and death from coronavirus disease-2019 (COVID-19). METHODS The SELECT (Semaglutide Effects on Cardiovascular Outcomes in Patients With Overweight or Obesity) trial randomized 17,604 participants $45 years of age with a body mass index $27 kg/m2 with established CV disease but without diabetes to once-weekly subcutaneous semaglutide 2.4 mg or placebo; the mean trial duration was 3.3 years. Adjudicated causes of all deaths, COVID-19 cases, and associated deaths were captured prospectively. RESULTS Of 833 deaths, 485 (58%) were CV deaths, and 348 (42%) were non-CV deaths. Participants assigned to semaglutide vs placebo had lower rates of all-cause death (HR: 0.81; 95% CI: 0.71-0.93), CV death (HR: 0.85; 95% CI: 0.71-1.01), and non-CV death (HR: 0.77; 95% CI: 0.62-0.95). The most common causes of CV death with semaglutide vs placebo were sudden cardiac death (98 vs 109; HR: 0.89; 95% CI: 0.68-1.17) and undetermined death (77 vs 90; HR: 0.85; 95% CI: 0.63-1.15). Infection was the most common cause of non-CV death and occurred at a lower rate in the semaglutide vs the placebo group (62 vs 87; HR: 0.71; 95% CI: 0.51-0.98). Semaglutide did not reduce incident COVID-19; however, among participants who developed COVID-19, fewer participants treated with semaglutide had COVID-19–related serious adverse events (232 vs 277; P 1⁄4 0.04) or died of COVID-19 (43 vs 65; HR: 0.66; 95% CI: 0.44- 0.96). High rates of infectious deaths occurred during the COVID-19 pandemic, with less infectious death in the semaglutide arm, and resulted in fewer participants in the placebo group being at risk for CV death. CONCLUSIONS Compared to placebo, patients treated with semaglutide 2.4 mg had lower rates of ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39217559; info:eu-repo/semantics/altIdentifier/wos/WOS:001342305600001; numberofpages:11; journal:JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY; https://hdl.handle.net/10447/658460 |
| DOI: |
10.1016/j.jacc.2024.08.007 |
| Availability: |
https://hdl.handle.net/10447/658460; https://doi.org/10.1016/j.jacc.2024.08.007 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.56068112 |
| Database: |
BASE |