| Title: |
Paternal high-fat diet consumption induces common changes in the transcriptomes of retroperitoneal adipose and pancreatic islet tissues in female rat offspring. |
| Authors: |
Sheau-Fang Ng; Ruby CY Lin; Christopher A Maloney; Neil A Youngson; Julie Owens; Margaret J Morris |
| Publication Year: |
2014 |
| Subject Terms: |
Biochemistry and cell biology not elsewhere classified; Animal physiology - biophysics; Animal physiology - cell; Animal physiology - systems; Medical physiology not elsewhere classified; chronic degenerative disorder; developmental programming; obesity; olfactory receptor genes; premature aging; Animals; Cluster Analysis; Diet; High-Fat; Dietary Fats; Female; Gene Regulatory Networks; Intra-Abdominal Fat; Islets of Langerhans; Male; Oligonucleotide Array Sequence Analysis; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Sprague-Dawley; Transcriptome |
| Description: |
We previously showed that paternal high-fat diet (HFD) consumption programs β-cell dysfunction in female rat offspring, together with transcriptome alterations in islets. Here we investigated the retroperitoneal white adipose tissue (RpWAT) transcriptome using gene and pathway enrichment and pathway analysis to determine whether commonly affected network topologies exist between these two metabolically related tissues. In RpWAT, 5108 genes were differentially expressed due to a paternal HFD; the top 5 significantly enriched networks identified by pathway analysis in offspring of HFD fathers compared with those of fathers fed control diet were: mitochondrial and cellular response to stress, telomerase signaling, cell death and survival, cell cycle, cellular growth and proliferation, and cancer. A total of 187 adipose olfactory receptor genes were down-regulated. Interrogation against the islet transcriptome identified specific gene networks and pathways, including olfactory receptor genes that were similarly affected in both tissues (411 common genes, P |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
http://hdl.handle.net/10536/DRO/DU:30116810 |
| Availability: |
http://hdl.handle.net/10536/DRO/DU:30116810; https://figshare.com/articles/journal_contribution/Paternal_high-fat_diet_consumption_induces_common_changes_in_the_transcriptomes_of_retroperitoneal_adipose_and_pancreatic_islet_tissues_in_female_rat_offspring_/20780212 |
| Rights: |
All Rights Reserved |
| Accession Number: |
edsbas.5616CB0B |
| Database: |
BASE |