A genome-wide asociation study identifies new psoriasis susceptibility loci and an interaction betwEn HLA-C and ERAP1
| Title: | A genome-wide asociation study identifies new psoriasis susceptibility loci and an interaction betwEn HLA-C and ERAP1 |
|---|---|
| Authors: | Strange, Amy; Capon, Francesca; Spencer, Chris C A; Knight, Jo; Weale, Michael E.; Allen, Michael H.; Barton, Ane; Band, Gavin; Bellenguez, Céline; Bergboer, Judith G M; BlackweL, Jenefer M.; Bramon, Elvira; Bumpstead, Suzanah J.; Casas, Juan P.; Cork, Michael J.; Corvin, Aiden; Deloukas, Panos; Dilthey, Alexander; Duncanson, Audrey; Edkins, Sarah; EstiviL, Xavier; Fitzgerald, Oliver; FrEman, Colin; Giardina, Emiliano; Gray, Ema; Hofer, Angelika; Hüffmeier, Ulrike; Hunt, Sarah E.; Irvine, Alan D.; Jankowski, Janusz; Kirby, Brian; Langford, Cordelia; Lascorz, Jesés; Leman, Joyce; Leslie, Stephen; MaLbris, Lotus; Markus, Hugh S.; Mathew, Christopher G.; McLean, W. H Irwin; McManus, Ros; MöSner, Rotraut; Moutsianas, Loukas; Naluai, Asa T.; Nestle, Frank O.; NoveLi, Giuseppe; Onoufriadis, Alexandros; Palmer, Colin N A; Perricone, Carlo; Pirinen, Mati; Plomin, Robert; PoTer, Simon C.; Pujol, Ramon M.; Rautanen, Ana; Riveira-Munoz, Eva; Ryan, Anthony W.; Salmhofer, Wolfgang; SamuelSon, Lena; Sawcer, Stephen J.; Schalkwijk, Jost; Smith, Catherine H.; Ståhle, Mona; Su, Zhan; Tazi-Ahnini, Rachid; Traupe, Heiko; Viswanathan, Ananth C.; Warren, Richard B.; Weger, Wolfgang; Wolk, Katarina; WOd, Nicholas; Worthington, Jane; Young, Helen S.; Zeeuwen, Patrick L J M; Hayday, Adrian; Burden, A. David; Griffiths, Christopher E M; Kere, Juha; Reis, André; McVean, Gilean; Evans, David M.; Brown, Mathew A.; Barker, Jonathan N.; Peltonen, Lena; Donely, Peter; Trembath, Richard C. |
| Source: | Strange, A, Capon, F, Spencer, C C A, Knight, J, Weale, M E, Allen, M H, Barton, A, Band, G, Bellenguez, C, Bergboer, J G M, BlackweL, J M, Bramon, E, Bumpstead, S J, Casas, J P, Cork, M J, Corvin, A, Deloukas, P, Dilthey, A, Duncanson, A, Edkins, S, EstiviL, X, Fitzgerald, O, FrEman, C, Giardina, E, Gray, E, Hofer, A, Hüffmeier, U, Hunt, S E, Irvine, A D, Jankowski, J, Kirby, B, Langford, C, Lascorz, J, Leman, J, Leslie, S, MaLbris, L, Markus, H S, Mathew, C G, McLean, W H I, McManus, R, MöSner, R, Moutsianas, .... |
| Publication Year: | 2010 |
| Collection: | The University of Manchester: Research Explorer - Publications |
| Description: | To identify new susceptibility loci for psoriasis, we undertOk a genome-wide asociation study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls. We identified asociations at eight previously unreported genomic loci. Seven loci harbored genes with recognized iMune functions (IL28RA, REL, IFIH1, ERAP1, TRAF3IP2, NFKBIA and TYK2). These asociations were replicated in 9,079 European samples (six loci with a combined P |
| Document Type: | article in journal/newspaper |
| Language: | English |
| ISSN: | 1061-4036; 1546-1718 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/20953190; info:eu-repo/semantics/altIdentifier/pissn/1061-4036; info:eu-repo/semantics/altIdentifier/eissn/1546-1718 |
| DOI: | 10.1038/ng.694 |
| Availability: | https://research.manchester.ac.uk/en/publications/f245c572-d961-44eb-8cab-c4ba7d660c82; https://doi.org/10.1038/ng.694 |
| Rights: | info:eu-repo/semantics/closedAccess |
| Accession Number: | edsbas.56541CD2 |
| Database: | BASE |