| Title: |
Characteristics and outcomes of neonates hospitalised with SARS-CoV-2 infection in the UK by variant: a prospective national cohort study. |
| Authors: |
Gale, C; Sharkey, D; Fitzpatrick, KE; Mactier, H; Morelli, A; Nakahara, M; Hurd, M; Placzek, A; Knight, M; Ladhani, SN; Draper, ES; Doherty, C; Quigley, MA; Kurinczuk, JJ; Neonatal complications of COVID-19 Collaborative Group |
| Publisher Information: |
BMJ Publishing Group |
| Publication Year: |
2024 |
| Collection: |
St George's University of London: Repository |
| Description: |
OBJECTIVE: Neonatal infection with wildtype SARS-CoV-2 is rare and good outcomes predominate. We investigated neonatal outcomes using national population-level data to describe the impact of different SARS-CoV-2 variants. DESIGN: Prospective population-based cohort study. SETTING: Neonatal, paediatric and paediatric intensive care inpatient care settings in the UK. PATIENTS: Neonates (first 28 days after birth) with confirmed SARS-CoV-2 infection who received inpatient care, March 2020 to April 2022. Neonates were identified through active national surveillance with linkage to national SARS-CoV-2 testing data, routinely recorded neonatal data, paediatric intensive care data and obstetric and perinatal mortality surveillance data. OUTCOMES: Presenting signs, clinical course, severe disease requiring respiratory support are presented by the dominant SARS-CoV-2 variant in circulation at the time. RESULTS: 344 neonates with SARS-CoV-2 infection received inpatient care; breakdown by dominant variant: 146 wildtype, 123 alpha, 57 delta and 18 omicron. Overall, 44.7% (153/342) neonates required respiratory support; short-term outcomes were good with 93.6% (322/344) of neonates discharged home. Eleven neonates died: seven unrelated to SARS-CoV-2 infection, four were attributed to neonatal SARS-CoV-2 infection (case fatality 4/344, 1.2% 95% CI 0.3% to 3.0%) of which three were born preterm due to maternal COVID-19. More neonates were born very preterm (23/54) and required invasive ventilation (27/57) when delta variant was predominant, and all four SARS-CoV-2-related deaths occurred in this period. CONCLUSIONS: Inpatient care for neonates with SARS-CoV-2 was uncommon. Although rare, severe neonatal illness was more common during the delta variant period, potentially reflecting more severe maternal disease and associated preterm birth. TRIAL REGISTRATION NUMBER: ISRCTN60033461. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
1468-2052 |
| Relation: |
https://openaccess.sgul.ac.uk/id/eprint/116327/1/archdischild-2023-326167.full.pdf; Gale, C; Sharkey, D; Fitzpatrick, KE; Mactier, H; Morelli, A; Nakahara, M; Hurd, M; Placzek, A; Knight, M; Ladhani, SN; et al. Gale, C; Sharkey, D; Fitzpatrick, KE; Mactier, H; Morelli, A; Nakahara, M; Hurd, M; Placzek, A; Knight, M; Ladhani, SN; Draper, ES; Doherty, C; Quigley, MA; Kurinczuk, JJ; Neonatal complications of COVID-19 Collaborative Group (2024) Characteristics and outcomes of neonates hospitalised with SARS-CoV-2 infection in the UK by variant: a prospective national cohort study. Arch Dis Child Fetal Neonatal Ed, 109 (3). pp. 279-286. ISSN 1468-2052 https://doi.org/10.1136/archdischild-2023-326167 SGUL Authors: Ladhani, Shamez Nizarali |
| DOI: |
10.1136/archdischild-2023-326167 |
| Availability: |
https://openaccess.sgul.ac.uk/id/eprint/116327/; https://doi.org/10.1136/archdischild-2023-326167 |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.565B3FC7 |
| Database: |
BASE |