| Title: |
P-417: Effect of baseline cognitive function on outcomes in the study on cognition and prognosis in the elderly (scope) |
| Authors: |
Skoog, Ingmar; Lithell, Hans; Elmfeldt, Dag; Hofman, Albert; Olofsson, Bertil; Trenkwalder, Peter; Zanchetti, Alberto |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2004 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Abstracts |
| Description: |
The Study on COgnition and Prognosis in the Elderly (SCOPE) was the first large-scale clinical trial to determine the effects of angiotensin II type 1 receptor blockade on cardiovascular and cognitive outcomes in elderly patients with mild to moderate hypertension. The present analysis evaluates whether cognitive function at baseline affected cognitive and cardiovascular outcomes in SCOPE. SCOPE included 4,937 patients, aged 70–89 years, with systolic blood pressure (BP) 160–179 mmHg and/or diastolic BP 90–99 mmHg, and Mini Mental State Examination (MMSE) score ≥24. Double-blind treatment was initiated with candesartan (8–16 mg once daily) or placebo. Open-label therapy was added as needed to control BP, both in the candesartan (49%) and control (66%) groups. Low cognitive function (LCF) at baseline was defined as MMSE score 24–28 (N=2,070), and high cognitive function (HCF) as MMSE score 29–30 (N=2,867). Mean age was 77.3 years in LCF patients and 75.8 years in HCF patients. Baseline characteristics were similar between candesartan and control groups both in LCF and HCF patients. Mean BP reductions were approximately 20/10 mmHg both in LCF and HCF patients. Differences in BP reductions between the candesartan and control groups, in favour of candesartan, were similar in LCF (2.5/1.9 mmHg) and HCF (3.3/1.5 mmHg) patients. The incidence of dementia (4.4% vs 1.0%) and major cardiovascular events (33.6 vs 24.7 per 1000 patient years) was higher in LCF than HCF patients (p |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://ajh.oxfordjournals.org/cgi/content/short/17/S1/186A-b; http://dx.doi.org/10.1016/j.amjhyper.2004.03.491 |
| DOI: |
10.1016/j.amjhyper.2004.03.491 |
| Availability: |
http://ajh.oxfordjournals.org/cgi/content/short/17/S1/186A-b; https://doi.org/10.1016/j.amjhyper.2004.03.491 |
| Rights: |
Copyright (C) 2004, American Journal of Hypertension, Ltd. |
| Accession Number: |
edsbas.569887BE |
| Database: |
BASE |