Midlife and late-life population attributable fractions of risk factors for dementia in the United States:The Dementia Risk Prediction Project
| Title: | Midlife and late-life population attributable fractions of risk factors for dementia in the United States:The Dementia Risk Prediction Project |
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| Authors: | Li, Joanne M.; Gauen, Abigail M.; Zmora, Rachel; Stephen, John J.; Petito, Lucia C.; Scholtens, Denise; Peterson, Elizabeth A.; Kohli-Lynch, Ciaran; Mansolf, Maxwell; Sedaghat, Sanaz; Giorgio, Katherine; Gross, Alden L.; Helmer, Catherine; Debette, Stéphanie; Soumaré, Aïcha; Ikram, M. Arfan; Wolters, Frank J.; Seshadri, Sudha; Satizabal, Claudia L.; Himali, Jayandra; Levine, Deborah A.; Briceño, Emily M.; Sorond, Farzaneh A.; Launer, Lenore J.; Li, David; Mbangdadji, Djass; Zhao, Lihui; Lloyd-Jones, Donald M.; Lopez, Oscar L.; Judd, Suzanne E.; Hughes, Timothy M.; Gudnason, Vilmundur; Aiello, Allison E.; Fohner, Alison; Singh-Manoux, Archana; Allen, Norrina B. |
| Source: | Li, J M, Gauen, A M, Zmora, R, Stephen, J J, Petito, L C, Scholtens, D, Peterson, E A, Kohli-Lynch, C, Mansolf, M, Sedaghat, S, Giorgio, K, Gross, A L, Helmer, C, Debette, S, Soumaré, A, Ikram, M A, Wolters, F J, Seshadri, S, Satizabal, C L, Himali, J, Levine, D A, Briceño, E M, Sorond, F A, Launer, L J, Li, D, Mbangdadji, D, Zhao, L, Lloyd-Jones, D M, Lopez, O L, Judd, S E, Hughes, T M, Gudnason, V, Aiello, A E, Fohner, A, Singh-Manoux, A & Allen, N B 2026, 'Midlife and late-life population attributable fractions .... |
| Publication Year: | 2026 |
| Subject Terms: | /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being |
| Description: | INTRODUCTION: Dementia prevalence is associated with modifiable factors. We quantified the contribution of dementia risk factors in midlife (45–64 years) and late life (≥ 65 years) in the United States. METHODS: Data from six community-based cohorts in the Dementia Risk Prediction Project (DRPP) were used. We estimated risk factor prevalence using nationally representative data. Cohort-specific Cox regression models were used to estimate the association between modifiable risk factors and incident dementia in midlife and late life. Hazard ratios were pooled using meta-analysis then used to calculate population attributable fractions (PAFs) and potential impact fractions. RESULTS: Midlife and late-life risk factors contributed to 22.7% and 16.5% of total dementia cases, respectively. Midlife obesity (PAF: 7.7%; 95% confidence interval [CI]: 4.9%–10.5%), lower education (PAF: 8.1%; 95% CI: 5.2%–11.1%), and late-life physical inactivity (PAF: 10.4%; 95% CI: 6.2%–14.5%) were the greatest contributors. DISCUSSION: Midlife and late-life modifiable risk factors contribute to dementia risk, highlighting a need for interventions across the life course. Highlights: Our sample included 37,931 participants across six pooled, longitudinal US cohorts. We observed midlife and late-life risk factors contributed to 22.7% and 16.5% of dementia cases, respectively. Midlife obesity, late-life physical inactivity, and lower education appear to be the greatest contributors to dementia risk. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1552-5260; 1552-5279 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/41559019; info:eu-repo/semantics/altIdentifier/pissn/1552-5260; info:eu-repo/semantics/altIdentifier/eissn/1552-5279 |
| DOI: | 10.1002/alz.71065 |
| Availability: | https://pure.eur.nl/en/publications/df1257fa-7a92-4cbd-ad8c-c6d9c3542ca8; https://doi.org/10.1002/alz.71065; https://pure.eur.nl/ws/files/229709253/Midlife_and_late-life_population_attributable_fractions_of_risk_factors_for_dementia_in_the_United_States.pdf; https://www.scopus.com/pages/publications/105028107202 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: | edsbas.56CB3573 |
| Database: | BASE |