| Title: |
Effects of icosapent ethyl according to baseline residual risk in patients with atherosclerotic cardiovascular disease: results from REDUCE-IT |
| Authors: |
Burger, Pascal M; Bhatt, Deepak L; Dorresteijn, Jannick A N; Koudstaal, Stefan; Mosterd, Arend; Martens, Fabrice M A C; Steg, Philippe Gabriel; Visseren, Frank L J; Ladner, Joanne; Kakish, Lily; Kakish, Ashley; Little, Amy L; Gerber, Jaime; Hinchion, Nancy J; Guarino, Janet; Raychok, Denise; Budzinski, Susan; Kelley-Garvin, Kathleen; Beckord, April; Schlinder, Jessica; Schwartzbard, Arthur; Cobos, Stanley; Freeman, Deborah; Abisalih, David; McCann, Dervilla; Guy, Kylie; Chase, Jennifer; Samuelson, Stacey; Cassidy, Madeline; Tardif, Marissa; Smith, Jaime; Sprout, Brenna; Riedeman, Nanette; Goza, Julie; Johnson, Lori; Kraske, Chad; Hastings, Sheila; Dutka, Chris; Smith, Stephanie; McCabe, Toni; Maloney, Kathleen; Alfieri, Paul; Hosemane, Vinay; Syravanh, Chanhsamone; Pau, Cindy; Limcoiloc, April; Carreira, Tabitha; Kurosawa, Taryn S; Krumian, Razmig |
| Contributors: |
Amarin Pharma |
| Source: |
European Heart Journal - Cardiovascular Pharmacotherapy ; volume 10, issue 6, page 488-499 ; ISSN 2055-6837 2055-6845 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2024 |
| Description: |
Aims Icosapent ethyl lowers triglycerides and significantly reduces major adverse cardiovascular events (MACE), though treatment effects may vary between individuals. This study aimed to determine the relative and absolute effects of icosapent ethyl on MACE according to baseline cardiovascular disease (CVD) risk in patients with atherosclerotic cardiovascular disease (ASCVD). Methods and Results Participants from the Reduction of Cardiovascular Events with Icosapent Ethyl—Intervention Trial (REDUCE-IT) with ASCVD were included (n = 5785). The primary outcome was 3-point MACE, i.e. non-fatal myocardial infarction, non-fatal stroke, or cardiovascular death. Baseline 5-year risk of MACE was estimated using the European Society of Cardiology (ESC) guideline-recommended SMART2 risk score. Modification of the relative treatment effects of icosapent ethyl by baseline risk was assessed using Cox proportional hazards models, including a treatment-by-risk interaction. Next, treatment effects were assessed stratified by quartiles of baseline risk. During a median follow-up of 4.8 years (interquartile range 3.2–5.3), MACE occurred in 361 vs. 489 patients in the icosapent ethyl vs. placebo group [95% confidence interval (CI)]; hazard ratio (HR) 0.72 (0.63–0.82), absolute risk reduction (ARR) 4.4% (2.6–6.2%), number needed to treat (NNT) 23 (16–38), and 5-year Kaplan-Meier estimated cumulative incidence reduction (CIR) 5.7% (3.5–7.9%). Icosapent ethyl significantly reduced MACE in all risk quartiles, with an HR (95% CI) of 0.62 (0.43–0.88), 0.66 (0.48–0.92), 0.69 (0.53–0.90), and 0.78 (0.63–0.96), respectively (P for treatment-by-risk interaction = 0.106). The ARR (95% CI) increased across risk quartiles, i.e. was 3.9% (1.0–6.8%), 4.3% (1.2–7.3%), 5.1% (1.4–8.7%), and 5.6% (1.3–10.0%), respectively. This translates to NNTs (95% CI) of 26 (15–98), 24 (14–84), 20 (11–70), and 18 (10–77). The 5-year CIR (95% CI) was 4.8% (1.3–8.2%), 5.0% (1.3–8.7%), 6.1% (1.7–10.5%), and 7.7% (2.3–13.2%), respectively. Consistent ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ehjcvp/pvae030 |
| DOI: |
10.1093/ehjcvp/pvae030/58663957/pvae030.pdf |
| Availability: |
https://doi.org/10.1093/ehjcvp/pvae030; https://academic.oup.com/ehjcvp/advance-article-pdf/doi/10.1093/ehjcvp/pvae030/58663957/pvae030.pdf; https://academic.oup.com/ehjcvp/article-pdf/10/6/488/59582281/pvae030.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.571E73D0 |
| Database: |
BASE |