| Title: |
Association of single nucleotide polymorphism in patatin like phopholipase domain containing 3 (PNPLA3) gene with paediatric non-alcoholic fatty liver disease |
| Authors: |
Alam, Rubaiyat; Fathema, Kaniz; Rukunuzzaman, Md; Nahid, Khan Lamia; Mahbuba, Sharmin; Akram, Lubana; Sattar, Abu Naser Ibne |
| Source: |
Bangabandhu Sheikh Mujib Medical University Journal; Vol. 16 No. 3 (2023); 139-143 ; 2224-7750 ; 2074-2908 |
| Publisher Information: |
Bangabandhu Sheikh Mujib Medical University (currently, Bangladesh Medical University) Vice Chancellor office, Room: 113, Block: B; Shahbag, Dhaka 1000 Tel: 55165600, 9661065; PABX: 4597, 6666; FAX: 88-02-55165601 Email: vc@bsmmu.edu.bd |
| Publication Year: |
2023 |
| Collection: |
Bangladesh Journals Online (BanglaJOL) |
| Subject Terms: |
children; fatty liver; obesity; PNPLA3 gene; single nucleotide polymorphism |
| Time: |
Bangladesh |
| Description: |
Background: Non-alcoholic fatty liver disease (NAFLD) is the most unabating cause of chronic liver disease in children and adolescents. This study aimed to examine the association of single nucleotide polymorphism in patatin-like phospholipase domain containing 3 (PNPLA3) gene with paediatric non-alcoholic fatty liver disease. Methods: This case-control study was conducted from June 2021 to December 2022. Fifty-one overweight children aged 6–17 years were recruited in this study and divided into NAFLD (cases) and non-NAFLD (controls) groups based on hepatic steatosis detected by liver ultrasonography. We analysed the rs738409 polymorphism by TaqMan assay and examined its association with NAFLD. Results: Thirty-one (60.8%) children were in the case group and 20 (39.2%) children were in the control group. Alanine aminotransferase (P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://banglajol.info/index.php/BSMMUJ/article/view/68260/46164; https://banglajol.info/index.php/BSMMUJ/article/view/68260 |
| Availability: |
https://banglajol.info/index.php/BSMMUJ/article/view/68260 |
| Rights: |
Copyright (c) 2023 Rubaiyat Alam, Kaniz Fathema, Md Rukunuzzaman, Khan Lamia Nahid, Sharmin Mahbuba, Lubana Akram, Abu Naser Ibne Sattar ; http://creativecommons.org/licenses/by/4.0 |
| Accession Number: |
edsbas.573AA143 |
| Database: |
BASE |