| Title: |
Effects of Exercise Duration and Intensity on Maximal Exercise Capacity Over 6 Months in Coronary Heart Disease and Type 2 Diabetes—A Secondary Analysis of the LeIKD Trial |
| Authors: |
Gass, Felix; Dinges, Sophia M.; Fegers‐Wustrow, Isabel; Freigang, Felix; Maier, Patrizia; Arnold, Matthias; Winzer, Ephraim B.; Edelmann, Frank; Wolfram, Oliver; Brandts, Julia; Wolfarth, Bernd; Dörr, Marcus; Wachter, Rolf; Hackenberg, Björn; Rust, Sarah; Nebling, Thomas; Amelung, Volker; Halle, Martin; Mueller, Stephan |
| Contributors: |
Gass, Felix; Dinges, Sophia M.; Fegers‐Wustrow, Isabel; Freigang, Felix; Maier, Patrizia; Arnold, Matthias; Winzer, Ephraim B.; Edelmann, Frank; Wolfram, Oliver; Brandts, Julia; Wolfarth, Bernd; Dörr, Marcus; Wachter, Rolf; Hackenberg, Björn; Rust, Sarah; Nebling, Thomas; Amelung, Volker; Halle, Martin; Mueller, Stephan |
| Publication Year: |
2026 |
| Collection: |
Georg-August-Universität Göttingen: GoeScholar |
| Description: |
Exercise training is recommended in coronary heart disease (CHD) and type 2 diabetes (T2DM) patients alike; however, uncertainty remains on the influence of exercise intensity and duration in older patients with both entities. To address this, we performed a secondary analysis including 201 patients (67.9 ± 8.2 years; 84.1% men) from the LeIKD trial (NCT038359), which introduced 6 months of home‐based telemedicine‐supported exercise intervention in patients with CHD and T2DM. We assessed the relationships between exercise duration and intensity with change in peak oxygen uptake (V̇O 2 peak) (simple and multiple regression analyses, α = 0.05). V̇O 2 peak increased by 0.42 mL/kg/min per hour of endurance exercise/week (95% CI: 0.17–0.66, p = 0.001). Exercise intensity was not significantly associated with the change in V̇O 2 peak ( p = 0.10). In a subgroup of patients with high adherence (≥ 66.7% of prescribed total duration and meeting prescribed exercise duration in ≥ 50% of weeks of intervention), a 10% increase in exercise intensity (mean % heart rate reserve (HRR)) was associated with an increase in V̇O 2 peak of 0.26 mL/kg/min (95% CI: 0.00–0.52; p = 0.05). Longer training duration within the initial 2 weeks of intervention was significantly associated with high adherence over 6 months (increased likelihood per 10 min/week: OR of 1.09 [95% CI: 1.05–1.14], p < 0.001). Therefore, exercise duration but not intensity influences changes in V̇O 2 peak during exercise intervention in a high‐risk population of older patients with CHD and T2DM. In patients with high adherence to exercise duration, higher exercise intensity led to an additional increase in V̇O 2 peak. Training duration within the first 2 weeks was an important predictor of long‐term adherence. Trial Registration: https://www.clinicaltrials.gov : Identifier: NCT038359 ; Gemeinsame Bundesausschuss https://doi.org/10.13039/501100014840 |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/sms.70209 |
| Availability: |
https://resolver.sub.uni-goettingen.de/purl?gro-2/158008; https://doi.org/10.1111/sms.70209 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.575DF928 |
| Database: |
BASE |