| Title: |
Psychological side effects of antipsychotic medication after remission from first-episode psychosis:a HAMLETT ecological momentary assessment study |
| Authors: |
Djordjevic, Matej; Gangadin, Shiral S.; De Haan, Lieuwe; Jongsma, Hannah E.; Oomen, Priscilla P.; Simons, Claudia J. P.; Marcelis, Machteld; Nijland, Mark; Begemann, Marieke J. H.; Sommer, Iris E. C.; Kikkert, Martijn J.; Veling, Wim |
| Source: |
Djordjevic, M, Gangadin, S S, De Haan, L, Jongsma, H E, Oomen, P P, Simons, C J P, Marcelis, M, Nijland, M, Begemann, M J H, Sommer, I E C, Kikkert, M J & Veling, W 2025, 'Psychological side effects of antipsychotic medication after remission from first-episode psychosis : a HAMLETT ecological momentary assessment study', Psychological Medicine, vol. 55, e325. https://doi.org/10.1017/S003329172510216X |
| Publication Year: |
2025 |
| Collection: |
Maastricht University Research Publications |
| Subject Terms: |
first-episode psychosis; antipsychotic medication; D-2 affinity; side effects; ecological momentary assessment; experience sampling methodology; schizophrenia spectrum disorder; early psychosis; psychopharm acology; SCHIZOPHRENIA SPECTRUM DISORDERS; 1ST EPISODE PSYCHOSIS; NEGATIVE SYMPTOMS; SUBJECTIVE EXPERIENCE; RECEPTOR OCCUPANCY; DRUGS; SELF; PSYCHOPATHOLOGY; OLANZAPINE; SYSTEM |
| Description: |
Background. Evidence on psychological side effects (PSEs) of antipsychotic medication after remission from first-episode psychosis (FEP), and their momentary impact on daily life, is limited. This study examined how Dopamine-2 (D-2) affinity and antipsychotic dosage relate to momentary PSEs. Methods. This ecological momentary assessment (EMA) study included baseline data from 56 participants in the ongoing Handling Antipsychotic Medication: Long-term Evaluation of Targeted Treatment (HAMLETT) trial. Momentary mental states indicative of reduced affect intensity, stability, and variability, as well as avolition and mental fatigue, were assessed 10x/day for eight days (N = 3,005 data points). Since these PSEs may result from D-2-receptor actions, antipsychotics were classified by receptor affinity and mechanism of action. Multilevel mixed-effects regression models examined serial cross-sectional associations between D-2 affinity or dosage and concurrent PSEs, both overall and separately for mornings, daytimes, and evenings. Results. Higher antipsychotic dosages were associated with reduced affect variability (Beta [B] = -1.40 [95% confidence interval [CI]: -2.52; -0.29]) and decreased positive affect stability (B = 0.23 [95% CI: 0.04; 0.42]) and intensity (B = -1.11 [95% CI: -1.97; -0.24]). The latter was also associated with the use of high-affinity D-2 antagonists versus partial D-2 agonists (B = 12.98 [95% CI: 2.43; 23.53]) and versus low-affinity D-2 antagonists (B = 10.04 [95% CI: 0.59; 19.49]). Other PSEs were not associated with D-2 affinity/dosage. Results were relatively consistent across daytimes. Conclusions. Higher antipsychotic dosage and high-affinity D-2 antagonists were associated with decreased positive affect after remission from FEP, which may partly drive the frequently reported blunting of emotional experience. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0033-2917; 1469-8978 |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/001604499300001; info:eu-repo/semantics/altIdentifier/pissn/0033-2917; info:eu-repo/semantics/altIdentifier/eissn/1469-8978 |
| DOI: |
10.1017/S003329172510216X |
| Availability: |
https://cris.maastrichtuniversity.nl/en/publications/a79ce639-fb67-4d5a-bdb5-98d10e130241; https://doi.org/10.1017/S003329172510216X |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.576D1232 |
| Database: |
BASE |