| Title: |
Consistency of Blood Pressure Response to Potassium-Enriched Salt in the China Salt Substitute Study |
| Authors: |
Kissock, K; Neal, B; Yuan, Y; Sundström, J; Jonsson, H; Rodgers, A; Wang, N; Huang, L; Wu, Y |
| Source: |
urn:ISSN:0194-911X ; urn:ISSN:1524-4563 ; Hypertension, Publish Ahead of Print, 1, 167-176 |
| Publisher Information: |
Wolters Kluwer |
| Publication Year: |
2025 |
| Collection: |
UNSW Sydney (The University of New South Wales): UNSWorks |
| Subject Terms: |
32 Biomedical and Clinical Sciences; 3202 Clinical Sciences; Cardiovascular; Hypertension; Humans; Male; Female; Blood Pressure; China; Middle Aged; Potassium; Dietary; Sodium Chloride; Adult; Blood Pressure Determination; biological variation; individual; potassium chloride; anzsrc-for: 32 Biomedical and Clinical Sciences; anzsrc-for: 3202 Clinical Sciences; anzsrc-for: 1102 Cardiorespiratory Medicine and Haematology; anzsrc-for: 1103 Clinical Sciences; anzsrc-for: 1117 Public Health and Health Services; anzsrc-for: 3201 Cardiovascular medicine and haematology |
| Description: |
BACKGROUND: – Large between-person differences in blood pressure (BP) responses to sodium reduction, potassium supplementation, and potassium-enriched salt have been suggested by prior studies. However, limitations in research designs and misinterpretation of findings mean that overestimation of true between-person variation in response is likely. METHODS: – Systolic BP (SBP) response during a 4-week run-in period on potassium-enriched salt was measured for 608 individuals. Participants were defined as apparently sensitive if SBP fell and apparently resistant if SBP was unchanged or rose. The effect of potassium-enriched salt compared with regular salt on SBP was then compared for apparently sensitive versus apparently resistant groups over a subsequent 12-month postrandomization period. A linear mixed model was used to determine how background within-person BP variability contributed to apparent between-person differences in BP response. RESULTS: – Apparent between-person variability in SBP response during run-in was substantial (mean SBP response, −13.7 [SD, 19.3; range, −80 to +56.5] mm Hg). Run-in identified 477 individuals as apparently sensitive and 131 as apparently resistant. Mean effects on SBP of potassium-enriched salt compared with regular salt over 12 months post-randomization were −2.2 mm Hg for apparently sensitive and −7.2 mm Hg for apparently resistant individuals, with no difference between the 2 groups (P=0.068). The mixed models identified no contribution of apparent run-in sensitivity to the observed between-person differences in postrandomization BP responses to potassium-enriched salt. CONCLUSIONS: – Individuals classified as responsive or resistant to potassium-enriched salt during initial exposure did not differ in their response to subsequent exposure. REGISTRATION: – URL: https://www.clinicaltrials.gov; Unique identifier: NCT00145756. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
https://hdl.handle.net/1959.4/107210; https://doi.org/10.1161/HYPERTENSIONAHA.125.24723 |
| DOI: |
10.1161/HYPERTENSIONAHA.125.24723 |
| Availability: |
https://hdl.handle.net/1959.4/107210; https://doi.org/10.1161/HYPERTENSIONAHA.125.24723 |
| Rights: |
open access ; https://purl.org/coar/access_right/c_abf2 ; CC BY-NC-ND ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.57B9D35 |
| Database: |
BASE |