| Title: |
Origin and spread of human mitochondrial DNA haplogroup U7 |
| Authors: |
Sahakyan, Hovhannes; Hooshiar Kashani, Baharak; Tamang, Rakesh; Kushniarevich, Alena; Francis, Amirtharaj; Costa, Marta D.; Pathak, Ajai Kumar; Khachatryan, Zaruhi; Sharma, Indu; van Oven, Mannis; Parik, Jüri; Hovhannisyan, Hrant; Metspalu, Ene; Pennarun, Erwan; Karmin, Monika; Tamm, Erika; Tambets, Kristiina; Bahmanimehr, Ardeshir; Reisberg, Tuuli; Reidla, Maere; Achilli, Alessandro; Olivieri, Anna; Gandini, Francesca; Perego, Ugo A.; Al-Zahery, Nadia; Houshmand, Massoud; Sanati, Mohammad Hossein; Soares, Pedro; Rai, Ekta; Šarac, Jelena; Šarić, Tena; Sharma, Varun; Pereira, Luisa; Fernandes, Veronica; Černý, Viktor; Farjadian, Shirin; Singh, Deepankar Pratap; Azakli, Hülya; Üstek, Duran; Ekomasova Trofimova, Natalia; Kutuev, Ildus; Litvinov, Sergei; Bermisheva, Marina; Khusnutdinova, Elza K.; Rai, Niraj; Singh, Manvendra; Singh, Vijay Kumar; Reddy, Alla G.; Tolk, Helle-Viivi; Cvjetan, Svjetlana; Lauc, Lovorka Barac; Rudan, Pavao; Michalodimitrakis, Emmanuel N.; Anagnou, Nicholas P.; Pappa, Kalliopi I.; Golubenko, Maria V.; Orekhov, Vladimir; Borinskaya, Svetlana A.; Kaldma, Katrin; Schauer, Monica A.; Simionescu, Maya; Gusar, Vladislava; Grechanina, Elena; Govindaraj, Periyasamy; Voevoda, Mikhail; Damba, Larissa; Sharma, Swarkar; Singh, Lalji; Semino, Ornella; Behar, Doron M; Yepiskoposyan, Levon; Richards, Martin B.; Metspalu, Mait; Kivisild, Toomas; Thangaraj, Kumarasamy; Endicott, Phillip; Chaubey, Gyaneshwer; Torroni, Antonio; Villems, Richard |
| Publisher Information: |
Nature Research |
| Publication Year: |
2017 |
| Collection: |
Universidade of Minho: RepositóriUM |
| Subject Terms: |
Bayes Theorem; DNA; Mitochondrial; Geography; Haplotypes; Humans; Mutation; Phylogeny; Evolution; Molecular; Science & Technology |
| Description: |
Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (~16-19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia. Here we report 267 new U7 mitogenomes that - analysed alongside 100 published ones - enable us to discern at least two distinct temporal phases of dispersal, both of which most likely emanated from the Near East. The earlier one began prior to the Holocene (~11.5 thousand years ago) towards South Asia, while the later dispersal took place more recently towards Mediterranean Europe during the Neolithic (~8 thousand years ago). These findings imply that the carriers of haplogroup U7 spread to South Asia and Europe before the suggested Bronze Age expansion of Indo-European languages from the Pontic-Caspian Steppe region. ; We thank all the DNA donors who participated in this study. This study was supported by Estonian Institutional Research grant IUT24-1 (to H.S., E.M., M.R., M.M., T.K., and R.V.); ERC Starting Investigator grant (FP7-261213) (to T.K.); EU European Regional Development Fund through the Centre of Excellence in Genomics to Estonian Biocentre; Estonian Research Council grant PUT1339 (to A.K.), PUT1217 (to Kr.T.) and PUT766 (to G.C.); the University of Pavia strategic theme "Towards a governance model for international migration: an interdisciplinary and diachronic perspective" (MIGRAT-IN-G); the Italian Ministry of Education, University and Research: Futuro in Ricerca 2012 (RBFR126B8I) (to A.A. and A.O.) and Progetti Ricerca Interesse Nazionale 2012 (to A.A., O.S., and A.T.); the Council of Scientific and ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
info:eu-repo/grantAgreement/EC/FP7/261213/EU; info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01641%2F2013%2FCP1158%2FCT0015/PT; https://www.nature.com/articles/srep46044.pdf; https://hdl.handle.net/1822/63890 |
| DOI: |
10.1038/srep46044 |
| Availability: |
https://hdl.handle.net/1822/63890; https://doi.org/10.1038/srep46044 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.57BAB732 |
| Database: |
BASE |