| Title: |
Comprehensive monitoring of cardiac remodeling with aortic stroke volume values provided by a phase-contrast MRI sequence |
| Authors: |
Marie, Pierre-Yves; Mandry, Damien; Huttin, Olivier; Micard, Emilien; Bonnemains, Laurent; Girerd, Nicolas; Beaumont, Marine; Fay, Renaud; Joly, Laure; Rossignol, Patrick; Benetos, Athanase; Felblinger, Jacques; Zannad, Faiez |
| Contributors: |
Service de Médecine Nucléaire CHRU Nancy; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy); Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Lorraine (UL); Département de Radiologie adultes CHRU Nancy; Imagerie Adaptative Diagnostique et Interventionnelle (IADI); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL); Défaillance Cardiovasculaire Aiguë et Chronique (DCAC); Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL); Service de Cardiologie CHRU Nancy; Centre d'investigation clinique plurithématique Pierre Drouin Nancy (CIC-P); Centre d'investigation clinique Nancy (CIC); Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL); Centre d'Investigation Clinique - Innovation Technologique Nancy (CIC-IT); Faculté de Médecine Nancy; Université de Lorraine (UL) |
| Source: |
ISSN: 0263-6352. |
| Publisher Information: |
CCSD; Lippincott, Williams & Wilkins |
| Publication Year: |
2016 |
| Collection: |
Université de Lorraine: HAL |
| Subject Terms: |
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Description: |
International audience ; OBJECTIVES:Blood pressure (BP) and its changes with antihypertensive therapy are key parameters when monitoring left ventricular (LV) remodeling. This dual cross-sectional and longitudinal MRI study aimed to determine whether this monitoring is enhanced by aortic stroke volume (SV) values provided by a phase-contrast sequence.METHODS:The study involved 334 MRI examinations from 247 study participants who had no significant cardiac disease (18-85 years old, 40% with hypertension) and among whom 48 had a 2-4-year MRI follow-up. Left ventricular hypertrophy and concentric geometry were: respectively assessed according to LV mass indexed to body surface area (g/m) and mass/end-diastolic volume ratio (concentric remodeling index); and correlated with vascular parameters involving BP and the indexed SV (ml/m) determined in the ascending aorta with a phase-contrast sequence.RESULTS:Stroke volume was highly variable, ranging from 22 to 74 ml/m. The best cross-sectional correlates were: mean BP × SV product, reflecting cardiac work, for LV mass (r = 0.21); and mean BP/SV ratio, reflecting arterial load, for concentric geometry (r = 0.29). These two SV-derived parameters led to more than two-fold enhancements in cross-sectional predictions compared with BP parameters alone, whereas their longitudinal changes over time paralleled those of concentric geometry (P = 0.003 for mean BP/SV) and LV mass (P = 0.006 for mean BP × SV), suggesting direct links with cardiac remodeling.CONCLUSION:The determination of aortic SV with a phase-contrast sequence leads to a significant enhancement in the characterization and monitoring of cardiac remodeling. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/26909645; PUBMED: 26909645 |
| DOI: |
10.1097/HJH.0000000000000889 |
| Availability: |
https://hal.univ-lorraine.fr/hal-01733041; https://doi.org/10.1097/HJH.0000000000000889 |
| Accession Number: |
edsbas.57FD05CE |
| Database: |
BASE |