| Title: |
Reducing self-harm in adolescents: the RISA-IPD comprehensive synopsis |
| Authors: |
Cottrell, David; Walwyn, Rebecca; Farrin, Amanda; Irving, Donna; Fonagy, Peter; Ougrin, Dennis; Stahl, Daniel; Wright, Judy; Wright-Hughes, Alex; RISA-IPD Collaborative Group |
| Source: |
Health Technology Assessment , 30 (3) pp. 1-52. (2026) |
| Publisher Information: |
National Institute for Health and Care Research |
| Publication Year: |
2026 |
| Collection: |
University College London: UCL Discovery |
| Description: |
Background: Self-harm is common in adolescents and a major public health concern. Evidence for effective interventions is lacking. An individual participant data meta-analysis has potential to provide more reliable estimates of the effects of therapeutic interventions than conventional meta-analyses and to explore which treatments are best suited to certain groups. // Methods: A systematic review and individual participant data meta-analysis of randomised controlled trials of therapeutic interventions to reduce repeat self-harm in adolescents with a history of self-harm and who had presented to clinical services. We searched Cochrane Library, EMBASE, trial registers and other databases for randomised controlled trials published in January 2022. Eligible randomised controlled trials compared any therapeutic intervention against a control, aimed to reduce self-harm in adolescents (11–18 years old), with past self-harm presenting to clinical services, and collected outcome data on self-harm or suicide attempts. Interventions reviewed were grouped into nine categories: cognitive–behavioural therapy; dialectical behaviour therapy; family therapy; group therapy; mentalisation based, psychodynamic, cognitive analytic therapy; multisystemic therapy; problem-solving, psychoeducation, support; postcards, tokens, documents (postcards/tokens); and other single session, brief interventions. Control interventions were all either treatment as usual or enhanced treatment as usual and were not usually well described. There were no ‘no treatment’ controls except in the postcard/document/token studies. Primary outcome was repetition of self-harm at 12 months. Other outcomes included repetition of self-harm at other time points, overall mental health, depressive symptoms, thoughts of suicide, quality of life and death. Two-stage random-effects individual participant data meta-analyses were conducted overall and by intervention, and to examine interaction between treatment received and participant characteristics. Secondary analyses ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10220624/1/3049553.pdf; https://discovery.ucl.ac.uk/id/eprint/10220624/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10220624/1/3049553.pdf; https://discovery.ucl.ac.uk/id/eprint/10220624/ |
| Rights: |
open |
| Accession Number: |
edsbas.58039FE9 |
| Database: |
BASE |