| Title: |
Impact of vascular architecture, oxygen saturation, and hematocrit on human cortical depth-dependent GE- and SE-BOLD fMRI signals:A simulation approach using realistic 3D vascular networks |
| Authors: |
Báez-Yáñez, Mario Gilberto; Siero, Jeroen C.W.; Curcic, Vanja; van Osch,Matthias J.P.; Petridou, Natalia; Neurovascular Imaging Group; Precision Imaging Group; Brain; Cancer |
| Publication Year: |
2025 |
| Subject Terms: |
7 tesla; biophysical modeling; laminar BOLD fMRI; layer fMRI; Monte Carlo simulations; oxygen saturation levels; realistic cortical vascular network; vessel size dependent hematocrit; Medicine (miscellaneous); Clinical Neurology; Radiology Nuclear Medicine and imaging; Neuroscience (miscellaneous); Journal Article |
| Description: |
Recent advancements in MRI hardware, including ultra-high magnetic field scanners (≥7T) and MR data acquisition methods, have enhanced functional imaging techniques, allowing for the detailed study of brain function, particularly at the mesoscopic level of cortical organization. This has enabled the measurement of blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal changes across cortical depth in the human brain, facilitating the study of neuronal activity at laminar level. In order to better understand the generation of cortical depth-dependent BOLD signals, biophysical modeling and computational simulations permit the characterization of the impact of vascular architecture, as well as the biophysical and hemodynamic effects at the mesoscopic level. In this study, we employed four realistic 3D vascular models that mimic the human cortical vascular architecture and simulated various vessel-dependent oxygen saturation and hematocrit states, aiming to characterize the intravascular and extravascular contributions to gradient-echo (GE) and spin-echo (SE) BOLD signal changes across human cortical depth at 7T. We found that differences in the local vascular architecture between the four models, away from the pial surface, do not significantly influence the shape and amplitude of BOLD profiles. This implies that signal profiles within a cortical region of a given angioarchitecture can be averaged within a given layer without introducing substantial errors in the results. The findings futher reveal that in deeper laminae, relative relaxation rates for both GE and SE decrease linearly with increasing oxygen saturation levels, with GE showing a stronger effect. In contrast, the top lamina shows a non-linear behavior due to large vessel contributions, particularly venous, with GE displaying higher relaxation rates (4–8 times larger dependent on oxygen saturation levels) than SE. Relative BOLD signal changes also follow linear trends in deeper layers, with GE peaking at ~8% and SE ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
2837-6056 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/467205 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/467205 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.5830819A |
| Database: |
BASE |