| Title: |
Different brain areas require different analysis models: fMRI observations in Parkinson's disease |
| Authors: |
Torrecuso, R.; Mueller, K.; Holiga, Š.; Urgosik, D.; Vymazal, J.; Sieger, T.; Růžička, F.; Růžička, E.; Schroeter, M.; Jech, R.; Möller, H. |
| Source: |
Proceedings of the ISMRM 31st Annual Meeting & Exhibition |
| Publication Year: |
2022 |
| Collection: |
Max Planck Society: MPG.PuRe |
| Description: |
Foreseeing how specific brain areas respond in time to a stimulus can be a prerequisite for a successfully conceived fMRI experiment. We demonstrate that in medicated Parkinson’s disease patients, putamen's activation peaks around the onset of tapping but does not persist throughout the tapping block, whereas sustained activation is observed in the motor cortex. Consequently, in the widely used tapping paradigm “On vs. Off L-DOPA”, the drug effect remains undetected if statistical analysis apply a block design instead of an event-related one. Ignoring this information can lead to fallacious conclusions which suggests using different models to investigate different brain regions. |
| Document Type: |
conference object |
| File Description: |
application/pdf |
| Language: |
unknown |
| Availability: |
http://hdl.handle.net/21.11116/0000-000B-1222-A; http://hdl.handle.net/21.11116/0000-000B-1224-8 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.588D18A8 |
| Database: |
BASE |