Long-term virological outcome in children on antiretroviral therapy in the UK and Ireland
| Title: | Long-term virological outcome in children on antiretroviral therapy in the UK and Ireland |
|---|---|
| Authors: | Duong T; Judd A; Collins IJ; Doerholt K; Lyall H; Foster C; Butler K; Tookey P; Shingadia D; Menson E; Dunn DT; Gibb DM; Kenny J; Bellenger K; Childs T; Dobson D; Johnson D; Tostevin A; Walker AS; Walker-Nthenda L; Tookey PA; Walsh A; Scott S; Vaughan Y; Welch S; Laycock N; Bernatoniene J; Finn A; Hutchison L; Sharpe G; Williams A; Lyall EGH; Seery P; Lewis P; Miles K; Subramaniam B; Hutchinson L; Ward P; Sloper K; Gopal G; Doherty C; Hague R; Price V; Bundy H; Clapson M; Flynn J; Klein N; Novelli V; Ainsley-Walker P; Tovey P; Gurtin D; Garside JP; Fall A; Porter D; Segal S; Ball C; Hawkins S; Chetcuti P; Dowie M; Bandi S; McCabe A; Eisenhut M; Handforth J; Roy PK; Flood T; Pickering A; Liebeschuetz S; Kavanagh C; Murphy C; Rowson K; Tan T; Daniels J; Lees Y; Kerr E; Thompson F; Le Provost M; Cliffe L; Smyth A; Stafford S; Freeman A; Reddy T; Fidler K; Christie S; Gordon A; Rogahn D; Harris S; Collinson A; Jones L; Offerman B; Van Someren V; Benson C; Riordan A; Riddell A; O'Connor R; Brown N; Ibberson L; Shackley F; Faust SN; Hancock J; Donaghy S; Prime K; Sharland M; Storey S; Gorman S; Monrose C; Tudor-Williams G; Walters S; Cross R; Broomhall J; Scott D; Stroobant J; Bridgwood A; McMaster P; Evans J; Gardiner T; Jones R; Gardiner K |
| Source: | AIDS, 2014 |
| Publisher Information: | Lippincott Williams and Wilkins |
| Publication Year: | 2014 |
| Collection: | Newcastle University Library ePrints Service |
| Description: | © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins. Objective: To assess factors at the start of antiretroviral therapy (ART) associated with long-term virological response in children. Design: Multicentre national cohort. Methods: Factors associated with viral load below 400copies/ml by 12 months and virologic failure among children starting 3/4-drug ART in the UK/Irish Collaborative HIV Paediatric Study were assessed using Poisson models. Results: Nine hundred and ninety-seven children started ART at a median age of 7.7 years (inter-quartile range 2.9-11.7), 251 (25%) below 3 years: 411 (41%) with efavirenz and two nucleoside reverse transcriptase inhibitors (EFV + 2NRTIs), 264 (26%) with nevirapine and two NRTIs (NVP + 2NRTIs), 119 (12%; 106 NVP, 13 EFV) with non-nucleoside reverse transcriptase inhibitor and three NRTIs (NNRTI+ 3NRTIs), and 203 (20%) with boosted protease inhibitor-based regimens. Median follow-up after ART initiation was 5.7 (3.0-8.8) years. Viral load was less than 400copies/ml by 12 months in 92% [95% confidence interval (CI) 91-94%] of the children. Time to suppression was similar across regimens (P = 0.10), but faster over calendar time, with older age and lower baseline viral load. Three hundred and thirtynine (34%) children experienced virological failure. Although progression to failure varied by regimen (P |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | unknown |
| Relation: | https://eprints.ncl.ac.uk/234180; https://eprints.ncl.ac.uk/fulltext.aspx?url=234180/7D59CBB0-BA25-4906-9820-BDDC2ABB2552.pdf&pub_id=234180 |
| Availability: | https://eprints.ncl.ac.uk/234180 |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: | edsbas.58A3E3DD |
| Database: | BASE |