| Title: |
Prolonged Posttreatment Virologic Control and Complete Seroreversion After Advanced Human Immunodeficiency Virus-1 Infection |
| Authors: |
Uruena, Analia; Cassetti, Isabel; Kashyap, Neena; Deleage, Claire; Estes, Jacob D; Trindade, Christopher; Hammoud, Dima A; Burbelo, Peter D; Natarajan, Ven; Dewar, Robin; Imamichi, Hiromi; Ward, Addison J; Poole, April; Ober, Alexander; Rehm, Catherine; Jones, Sara; Liang, C Jason; Chun, Tae-Wook; Nath, Avindra; Lane, H Clifford; Smith, Bryan R; Connors, Mark; Migueles, Stephen A |
| Contributors: |
Intramural Research Programs of National Institutes of Allergy and Infectious Diseases; National Institute of Dental and Craniofacial Research; National Cancer Institute; National Institutes of Health |
| Source: |
Open Forum Infectious Diseases ; volume 8, issue 1 ; ISSN 2328-8957 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2020 |
| Description: |
Background Possible human immunodeficiency virus (HIV)-1 clearance has rarely been reported. In this study, we describe a unique case of an HIV-positive, combination antiretroviral therapy (cART)-experienced woman with prior acquired immunodeficiency syndrome (AIDS) who has not experienced viral rebound for over 12 years since discontinuing cART. Methods Leukapheresis, colonoscopy, and lymph node excision were performed for detailed examination of virologic (including HIV reservoir) and immunologic features. Comparisons were made with chronically infected patients and healthy controls. Results No HIV-specific antibodies were detected in serum. Plasma HIV ribonucleic acid (RNA) levels were |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ofid/ofaa613 |
| DOI: |
10.1093/ofid/ofaa613/34927411/ofaa613.pdf |
| Availability: |
https://doi.org/10.1093/ofid/ofaa613; http://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofaa613/34927411/ofaa613.pdf; http://academic.oup.com/ofid/article-pdf/8/1/ofaa613/36149881/ofaa613.pdf |
| Accession Number: |
edsbas.58BDC14 |
| Database: |
BASE |