| Title: |
Psychiatric Symptoms and Cognitive Disorders in Behçet’s Disease: A Single-Center, Cross-Sectional Study |
| Authors: |
Urbain, Fanny; Hardy-Léger, Isabelle; Adebs-Nasser, Ghaidaa; de Menthon, Mathilde; Pivert, Cécile; Mausoléo, Aude; Laparra, Ariane; Lerolle, Nathalie; Domnariu, Paul Albert; Lambotte, Olivier; Denier, Christian; Goujard, Cécile D.Sign©cile; Castro-Gordon, Alicia; Noel, Nicolas |
| Contributors: |
Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Cohortes épidémiologiques en population (CONSTANCES); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité); Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse; AP-HP. Université Paris Saclay-AP-HP. Université Paris Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay |
| Source: |
ISSN: 2077-0383 ; Journal of Clinical Medicine ; https://hal.science/hal-04106350 ; Journal of Clinical Medicine, 2023, 12 (9), ⟨10.3390/jcm12093149⟩. |
| Publisher Information: |
CCSD; MDPI |
| Publication Year: |
2023 |
| Collection: |
Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| Subject Terms: |
Behçet’s disease; cognitive impairment; neuropsychiatry; psychopathology; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Background: Behçet’s disease (BD) is a rare form of vasculitis involving both veins and arteries of all calibers. Psychological symptoms and cognitive impairment appear to be frequent, but few data are available. Methods: All consecutive patients in our center fulfilling the 2013 BD criteria underwent a psychometric evaluation with auto- (SCL-90-R and Modified Fatigue Index) and hetero-questionnaires (MINI). A standardized test battery assessed cognitive dysfunction. Data were correlated with BD activity as well as quality of life (SF-36). Results: We included 20 consecutive patients (16 men, four women) with a median [IQR] age of 38 (30.0–45.5) and a median disease duration of 7 years (1.8–11.0). Five patients had an abnormal brain MRI. The SCL-90-R questionnaire highlighted eight psychopathological profiles (42.1%) that correlated with altered quality of life and more severe fatigue. The most frequent symptoms were anxiety (9/19, 47.4%), somatization (8/19, 42.1%) and phobia (5/19, 26.3%). Psychopathological symptoms appeared to be more severe, but not more frequent, in neuro-Behçet’s patients. Based on standardized cognitive evaluation, nine patients had cognitive impairment defined by three or more altered tests. Notably, 6/9 patients did not have any complaint of memory loss and were thus considered ansognostic. Conclusion: Cognitive involvement was significantly associated with BD activity score (BSAS) but not with brain MRI abnormalities. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.3390/jcm12093149 |
| Availability: |
https://hal.science/hal-04106350; https://hal.science/hal-04106350v1/document; https://hal.science/hal-04106350v1/file/jcm-12-03149-v2.pdf; https://doi.org/10.3390/jcm12093149 |
| Rights: |
http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.595509C9 |
| Database: |
BASE |