| Title: |
APOE ε4 and MBL-2 O/O genotypes are associated with neurocognitive impairment in HIV-infected plasma donors |
| Authors: |
Spector, SA; Singh, KK; Gupta, S; Cystique, LA; Jin, H; Letendre, S; Schrier, R; Wu, Z; Hong, KX; Yu, X; Shi, C; Heaton, RK; Cysique, Lucette |
| Source: |
urn:ISSN:0269-9370 ; urn:ISSN:1473-5571 ; AIDS, 24, 10, 1471-1479 |
| Publisher Information: |
Wolters Kluwer |
| Publication Year: |
2010 |
| Collection: |
UNSW Sydney (The University of New South Wales): UNSWorks |
| Subject Terms: |
3207 Medical Microbiology; 32 Biomedical and Clinical Sciences; Infectious Diseases; Mental Health; Brain Disorders; HIV/AIDS; Genetics; Behavioral and Social Science; Neurosciences; Acquired Cognitive Impairment; Neurodegenerative; Human Genome; Clinical Research; 2.1 Biological and endogenous factors; Infection; 3 Good Health and Well Being; Adult; Apolipoproteins E; Blood Donors; China; Cognition Disorders; Disease Progression; Female; Genotype; HIV Infections; HIV-1; Humans; Male; Mannose-Binding Lectin; Neuropsychological Tests |
| Description: |
Background: Host genetic factors are important determinants for risk of HIV-1 infection and disease progression. This study examined associations of host genetic variants and neurocognitive impairment in Chinese individuals infected through contaminated blood products. Methods: Two hundred and one HIV-infected patients from Anhui, China, had neuropsychological tests at baseline and 12 months. DNA was genotyped for APOE ε2, ε3 and ε4 alleles; MBL2-A/O; CCR5-wt/Δ32; CCR5-59029-G/A; CCR2-180-G/A; SDF-1-G/A; IL4-589-C/T; MCP-1-2518-A/G; CX 3 CR1-745-G/ A;-849-C/T polymorphisms and CCL3L1 copy number variants using real-time PCR. Univariate and multivariate analyses were performed. Results: The cohort included 61% men, with mean education 5.5 years, AIDS diagnosis 113 (55%), on antiretrovirals 114 (56%), mean baseline CD4 cell count 349 cells/μl and mean log10 RNA 4.09. At baseline, 37% had global neuropsychological impairment increasing to 44% after 12 months. Of 43 patients with the APOE ε4 allele, 58% were cognitively impaired compared with 31% without the ε4 allele (P = 0.001, odds ratio 3.09, 95% confidence interval 1.54-6.18). The mean global deficit score (GDS) for ε4-positive participants on antiretrovirals for 12 months was 0.88 (0.55) compared with 0.63 (0.54) for ε4-negative participants (P = 0.053, 95% confidence interval-0.004 to 0.51). For MBL2, 52% of patients with the O/O genotype declined in cognitive function over 12 months compared with 23% with A/A (odds ratio 3.62, 95% confidence interval 1.46-9.03, P = 0.004). No associations were observed for the other genetic variants. Conclusion: The APOE ε4 allele was associated with increased risk for cognitive deficits, whereas the MBL2 O/O genotype was associated with increased risk for progressive cognitive decline in Chinese individuals infected with HIV through contaminated blood products. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://hdl.handle.net/1959.4/unsworks_12904; https://doi.org/10.1097/QAD.0b013e328339e25c |
| DOI: |
10.1097/QAD.0b013e328339e25c |
| Availability: |
https://hdl.handle.net/1959.4/unsworks_12904; https://unsworks.unsw.edu.au/bitstreams/44546dfa-aa08-498c-b35d-5bacea13a8b2/download; https://doi.org/10.1097/QAD.0b013e328339e25c |
| Rights: |
open access ; https://purl.org/coar/access_right/c_abf2 ; CC-BY-NC-ND ; https://creativecommons.org/licenses/by-nc-nd/4.0/ ; free_to_read |
| Accession Number: |
edsbas.595D71B1 |
| Database: |
BASE |