| Title: |
Amygdala-related electrical fingerprint is modulated with neurofeedback training and correlates with deep-brain activation: proof-of-concept in borderline personality disorder |
| Authors: |
Zopfs, Malte; Jindrová, Miroslava; Gurevitch, Guy; Keynan, Jackob N; Hendler, Talma; Baumeister, Sarah; Aggensteiner, Pascal-M; Cornelisse, Sven; Brandeis, Daniel; Schmahl, Christian; Paret, Christian |
| Source: |
Zopfs, Malte; Jindrová, Miroslava; Gurevitch, Guy; Keynan, Jackob N; Hendler, Talma; Baumeister, Sarah; Aggensteiner, Pascal-M; Cornelisse, Sven; Brandeis, Daniel; Schmahl, Christian; Paret, Christian (2024). Amygdala-related electrical fingerprint is modulated with neurofeedback training and correlates with deep-brain activation: proof-of-concept in borderline personality disorder. Psychological Medicine, 54(8):1651-1660. |
| Publisher Information: |
Cambridge University Press |
| Publication Year: |
2024 |
| Collection: |
University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| Subject Terms: |
Child and Adolescent Psychiatry; Neuroscience Center Zurich; 610 Medicine & health; EEG; amygdala; borderline personality disorder; emotion regulation; fMRI; neurofeedback; neuroimaging; post-traumatic stress disorder; psychopathology |
| Description: |
Background: The modulation of brain circuits of emotion is a promising pathway to treat borderline personality disorder (BPD). Precise and scalable approaches have yet to be established. Two studies investigating the amygdala-related electrical fingerprint (Amyg-EFP) in BPD are presented: one study addressing the deep-brain correlates of Amyg-EFP, and a second study investigating neurofeedback (NF) as a means to improve brain self-regulation. Methods: Study 1 combined electroencephalography (EEG) and simultaneous functional magnetic resonance imaging to investigate the replicability of Amyg-EFP-related brain activation found in the reference dataset (N = 24 healthy subjects, 8 female; re-analysis of published data) in the replication dataset (N = 16 female individuals with BPD). In the replication dataset, we additionally explored how the Amyg-EFP would map to neural circuits defined by the research domain criteria. Study 2 investigated a 10-session Amyg-EFP NF training in parallel to a 12-weeks residential dialectical behavior therapy (DBT) program. Fifteen patients with BPD completed the training, N = 15 matched patients served as DBT-only controls. Results: Study 1 replicated previous findings and showed significant amygdala blood oxygenation level dependent activation in a whole-brain regression analysis with the Amyg-EFP. Neurocircuitry activation (negative affect, salience, and cognitive control) was correlated with the Amyg-EFP signal. Study 2 showed Amyg-EFP modulation with NF training, but patients received reversed feedback for technical reasons, which limited interpretation of results. Conclusions: Recorded via scalp EEG, the Amyg-EFP picks up brain activation of high relevance for emotion. Administering Amyg-EFP NF in addition to standardized BPD treatment was shown to be feasible. Clinical utility remains to be investigated. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0033-2917 |
| Relation: |
https://www.zora.uzh.ch/id/eprint/254540/1/ZORA_div_class_title_amygdala_related_electrical_fingerprint_is_modulated_with_neurofeedback_training_and_correlates_with_deep_brain_activation_proof_of_concept_in_borderline_personality_disorder_div.pdf; info:pmid/38131344; urn:issn:0033-2917 |
| DOI: |
10.1017/s0033291723003549 |
| Availability: |
https://www.zora.uzh.ch/id/eprint/254540/; https://www.zora.uzh.ch/id/eprint/254540/1/ZORA_div_class_title_amygdala_related_electrical_fingerprint_is_modulated_with_neurofeedback_training_and_correlates_with_deep_brain_activation_proof_of_concept_in_borderline_personality_disorder_div.pdf; https://doi.org/10.1017/s0033291723003549 |
| Rights: |
info:eu-repo/semantics/openAccess ; Creative Commons: Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.5968D972 |
| Database: |
BASE |