| Title: |
Associations of N-Terminal Pro-Brain Natriuretic Peptide with Incident Chronic Kidney Disease and All-Cause Mortality in Patients with No History of Heart Failure and Diabetes |
| Authors: |
Kuo, YN; Lin, CH; Wang, JS |
| Source: |
Nigerian Journal of Clinical Practice ; volume 28, issue 12, page 1470-1477 ; ISSN 1119-3077 2229-7731 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2025 |
| Description: |
Background: N-terminal pro-brain natriuretic peptide (NT-proBNP) is associated with morbidity and mortality due to heart failure and cardiovascular disease. Aim: We aimed to examine the association of NT-proBNP with incident chronic kidney disease (CKD) in patients with no history of heart failure and diabetes. Methods: We prospectively enrolled patients with no history of diabetes who underwent an oral glucose tolerance test to screen for diabetes between 2011 and 2013. Patients with a diagnosis of heart failure, and those who had an estimated glomerular filtration rate (eGFR) 125 vs. ≤125 pg/mL) with incident CKD (defined as an eGFR 125 vs. ≤125 pg/mL) at baseline were associated with a higher risk of incident CKD and all-cause mortality (hazard ratio [HR] 2.54, 95% CI 1.34 to 4.82, P = 0.004). This risk remained significant after multivariate adjustment (adjusted HR 2.23, 95% CI 1.10 to 4.52, P = 0.026). Conclusion: A higher NT-proBNP (>125 vs. ≤125 pg/mL) was independently associated with risk of incident CKD and all-cause mortality in patients with no history of heart failure and diabetes. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.4103/njcp.njcp_567_25 |
| Availability: |
https://doi.org/10.4103/njcp.njcp_567_25; https://journals.lww.com/10.4103/njcp.njcp_567_25 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.597B8DC4 |
| Database: |
BASE |