| Title: |
Auranofin improves overall survival when combined with standard of care in a pilot study involving dogs with osteosarcoma |
| Authors: |
Endo-Munoz, Liliana; Bennett, Tristram C.; Topkas, Eleni; Wu, Sherry Y.; Thamm, Douglas H.; Brockley, Laura; Cooper, Maureen; Sommerville, Scott; Thomson, Maurine; O'Connell, Kathleen; Lane, Amy; Bird, Guy; Peaston, Anne; Matigian, Nicholas; Straw, Rodney C.; Saunders, Nicholas A. |
| Publisher Information: |
Wiley-Blackwell Publishing Ltd. |
| Publication Year: |
2020 |
| Collection: |
James Cook University, Australia: ResearchOnline@JCU |
| Description: |
Osteosarcoma is the most common paediatric primary bone malignancy. The major cause of death in osteosarcoma is drug-resistant pulmonary metastasis. Previous studies have shown that thioredoxin reductase 2 is a driver of metastasis in osteosarcoma and can be inhibited by auranofin (AF). Moreover, studies have shown that AF significantly reduces pulmonary metastases in xenotransplant models. Here, we describe a phase I/II study of AF in canine osteosarcoma, a well-recognized spontaneous model of human osteosarcoma. We performed a single-arm multicentre pilot study of AF in combination with standard of care (SOC) (amputation + carboplatin). We recruited 40 dogs to the trial and used a historical SOC-only control group (n = 26). Dogs >15 kg received 9 mg AF q3d PO and dogs |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://doi.org/10.1111/vco.12533; https://researchonline.jcu.edu.au/60926/; https://researchonline.jcu.edu.au/60926/1/60926.pdf |
| Availability: |
https://researchonline.jcu.edu.au/60926/1/60926.pdf |
| Rights: |
restricted |
| Accession Number: |
edsbas.598C1CE5 |
| Database: |
BASE |