| Title: |
Global, regional, and national burden of disorders affecting the nervous system, 1990–2021 : a systematic analysis for the Global Burden of Disease Study 2021 |
| Authors: |
GBD 2021 Nervous System Disorders Collaborators; Steinmetz, Jaimie D.; Seeher, Katrin Maria; Schiess, Nicoline; Nichols, Emma; Cao, Bochen; Servili, Chiara; Cavallera, Vanessa; Cousin, Ewerton; Hagins, Hailey; Moberg, Madeline E.; Mehlman, Max L.; Abate, Yohannes Habtegiorgis; Abbas, Jaffar; Abbasi, Madineh Akram; Abbasian, Mohammadreza; Abbastabar, Hedayat; Abdelmasseh, Michael; Abdollahi, Mohammad; Abdollahi, Mozhan; Abdollahifar, Mohammad Amin; Abd-Rabu, Rami; Abdulah, Deldar Morad; Abdullahi, Auwal; Abedi, Aidin; Abedi, Vida; Abeldaño Zuñiga, Roberto Ariel; Abidi, Hassan; Abiodun, Olumide; Aboagye, Richard Gyan; Abolhassani, Hassan; Aboyans, Victor; Ahmad, Aqeel; Ashraf, Muhammad; Hossain, Md Mahbub; Kivimäki, Mika; Kumar, Ashish; Lallukka, Tea; Li, Wei; Meretoja, Atte; Nguyen, Ngoc Trinh Thi; Rodrigues, Mónica; Salem, Marwa Rashad; Shahabi, Saeed; Shiri, Rahman; Singh, Garima; Wang, Fang; Wang, Yuan Pang; Zakham, Fathiah; Zhang, Zhi Jiang; Zhao, Yang |
| Contributors: |
Helsinki Institute of Urban and Regional Studies (Urbaria); Centre for Social Data Science, CSDS; Clinicum; Department of Public Health; Helsinki Inequality Initiative (INEQ); HUS Group; Department of Virology; Faculty Common Matters (Faculty of Medicine); Helsinki One Health (HOH) |
| Publisher Information: |
Elsevier Ltd. |
| Publication Year: |
2024 |
| Collection: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| Subject Terms: |
Neurology and psychiatry; Neurological disorders; Prevention; Stroke |
| Description: |
Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021. Methods: We estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined. Findings: Globally, the 37 ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Funding was provided by the Gates Foundation (OPP 1152504). Q Gan acknowledges support from the International Agency for Research on Cancer Research and Training Programme. L Monasta, L Ronfani, and G Zamagni acknowledge support from the Italian Ministry of Health (Ricerca Corrente 34/2017), from grant payments made to the Institute for Maternal and Child Health Istituto di Ricovero e Cura a Carattere Scientifico Burlo Garofolo.; https://hdl.handle.net/10138/576416; 85187999548; 001270049900001 |
| Availability: |
https://hdl.handle.net/10138/576416 |
| Rights: |
cc_by ; info:eu-repo/semantics/openAccess ; openAccess |
| Accession Number: |
edsbas.5A1F837A |
| Database: |
BASE |